ArticleMolecular biology reports2011
DD genotype of ace gene I/D polymorphism is associated in a Turkish study population with osteoarthritis.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association between angiotensin-converting enzyme (ACE) gene I/D polymorphism with the risk of knee OA: A systematic review, meta-analysis, and meta-regression.F1000Research · 2024Pooled it
- Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population.Bioscience reports · 2019Pooled it
- Dynamic interaction of obesity, age, MCP-1 Level, and ACE-1 gene with the severity of knee osteoarthritis: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms.Molecular biology reports · 2019Article
- Association of GSTM1, GSTT1, GSTP1-ILE105VAL and ACE I/D polymorphisms with ankylosing spondylitis.Rheumatology international · 2016Article
- Association between the ACE gene I/D polymorphism and osteoporosis in a Turkish population.Zeitschrift fur Rheumatologie · 2015Article
- Association between ACE I/D polymorphism and pulmonary tuberculosis in Chinese population.Molecular biology reports · 2014Article
- Synergism between paraoxonase Arg 192 and the angiotensin converting enzyme D allele is associated with severity of coronary artery disease.Molecular biology reports · 2012Article
- Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis.Molecular vision · 2012Article
- Lack of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and osteoarthritis.Rheumatology international · 2012Article
- Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain.Molecular biology reports · 2011Article
- Genetic epidemiology of hip and knee osteoarthritis.Nature reviews. Rheumatology · 2011Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was conducted in Turkish osteoarthritis patients to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene, and to examine the role of this polymorphism in osteoarthritis development. Genomic DNA obtained from 200 persons (135 patients with osteoarthritis and 65 healthy controls) was used in the study. DNA was multiplied by polymerase chain reaction using I and D allele-specific primers. Polymerase chain reaction products were assessed with CCD camera by being exposed to 2% agarose gel electrophoresis. There was statistically significant difference between the groups with respect to genotype distribution (P < 0.001). The D allele frequency was indicated as 69% and I allele was as 31% in the patients, whereas it was 55-45% in the control group. Consequently, in this study, we may assert that ACE gene I/D polymorphism DD genotype determination is significant criteria for identifying patients who are likely to develop osteoarthritis in east population of Turkey.
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