ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Inflammation as death or life signal in diabetic fracture healing.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism.Journal of cellular biochemistry · 2026Article
- Experimental Gestational Diabetes Mellitus Prolongs Post-Incisional Mechanical Hypersensitivity and Increases Cutaneous Neuro-Immune Markers in Adult Female Offspring.Journal of pain research · 2026Article
- Biomaterial regulation of excessive inflammation restores osteoimmune homeostasis in diabetic bone regeneration.Regenerative biomaterials · 2026Review
- Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice.eLife · 2023Article
- Article
- Do Clinical Outcomes and Sagittal Parameters Differ Between Diabetics and Nondiabetics for Degenerative Spondylolisthesis Undergoing Lumbar Fusion?Global spine journal · 2020Article
- Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus.JBMR plus · 2020Article
- AdipoRon promotes diabetic fracture repair through endochondral ossification-based bone repair by enhancing survival and differentiation of chondrocytes.Experimental cell research · 2020Article
- Bone health in diabetes and prediabetes.World journal of diabetes · 2019Review
- Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki rats.The journal of physiological sciences : JPS · 2018Article
- The Impact of Type 2 Diabetes on Bone Fracture Healing.Frontiers in endocrinology · 2018Review
- Article
- Detection of RAGE expression and its application to diabetic wound age estimation.International journal of legal medicine · 2017Article
- Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.Stem cell research & therapy · 2017Article
- Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts.Current osteoporosis reports · 2016Review
- Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation.Journal of biomedical materials research. Part A · 2016Article
- Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.Inflammation · 2016Article
- A new in vivo model using a dorsal skinfold chamber to investigate microcirculation and angiogenesis in diabetic wounds.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2016Article
- miR-223 contributes to the AGE-promoted apoptosis via down-regulating insulin-like growth factor 1 receptor in osteoblasts.Bioscience reports · 2016Article
- Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis.Tissue engineering. Part B, Reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased apoptosis of chondrocytes and osteoblasts and prolonged survival of osteoclasts lead to early destruction of callus tissue and impair bone remodeling in fracture healing of diabetic patients. Diabetes is accompanied by an increased inflammatory state, reactive oxygen species (ROS) generation and accumulation of advanced glycation end products (AGEs), a heterogenous group of toxic metabolites that can induce inflammation. Prolonged hyperglycemia and insulin resistance correlate with increased apoptosis rate and, accordingly, the proapoptotic role of several inflammatory mediators, ROS and AGEs has been also documented. In this review we summarize the most recent reports supporting the idea that inflammatory signaling increases chondrocyte and osteoblast death and prolongs osteoclast survival, resulting in impaired bone regeneration in diabetes. Antagonising inflammatory signal pathways and solution of inflammation may deserve greater attention in the management of diabetic fracture healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.