ArticleIntensive care medicine2010
Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model.
Article in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- A practical predictive model to predict 30-day mortality in neonatal sepsis.Revista da Associacao Medica Brasileira (1992) · 2024Article
- B2M is a Biomarker Associated With Immune Infiltration In High Altitude Pulmonary Edema.Combinatorial chemistry & high throughput screening · 2024Article
- The role of human milk feeds on inotrope use in newborn infants with sepsis.Frontiers in pediatrics · 2023Article
- Hemodynamic dysfunction in neonatal sepsis.Pediatric research · 2022Review
- Sepsis and Oxidative Stress in the Newborn: From Pathogenesis to Novel Therapeutic Targets.Oxidative medicine and cellular longevity · 2018Review
- Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients.Critical care (London, England) · 2016Article
- Could Biomarkers Direct Therapy for the Septic Patient?The Journal of pharmacology and experimental therapeutics · 2016Review
- Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.Journal of neuroinflammation · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction.Pulmonary circulation · 2014Article
- Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis.Journal of clinical immunology · 2011Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate effects of endothelin receptor antagonist ETR-P1/fl in a neonatal sepsis model.
methodEighteen anesthetized and mechanically ventilated 3-day-old piglets were divided into three groups. Six piglets received cecal ligation and perforation (CLP group). Six piglets were administrated a continuous infusion of ETR-P1/fl (0.05 mg/kg/h), an antisense homology box-derived peptide with an endothelin A receptor antagonist effect, starting 30 min after CLP (ETR-P1/fl group). Six piglets acted as the sham group. Mean arterial pressure (MAP), heart rate, cardiac output, arterial blood gas, body temp (BT), serum nitrite and nitrate (NOx), tumor necrosis factor (TNF)-α, and high-mobility group box 1 (HMGB-1) were measured before CLP and at 1, 3, 6, and 9 h after CLP.
resultsCecal ligation and perforation exposure evoked a state of shock and showed deteriorated cardiac output, pulmonary hypertension, decreased MAP, low oxygen saturation, and base excess (BE) with elevated TNF-α, NOx, and HMGB1. ETR-P1/fl administration resulted in higher MAP at 6 and 9 h after CLP, less negative BE, lower mean pulmonary arterial pressure (mPAP)/MAP ratio at 9 h after CLP, and lower TNF-α, NOx, and HMGB-1 compared to the CLP group. BT showed no differences between the groups. Survival time in the ETR-P1/fl group was longer than in the CLP group (18.9 ± 2.3 h vs. 9.0 ± 0.8 h, p < 0.01).
conclusionsETR-P1/fl treatment significantly attenuated the elevation of NOx, TNF-α, and HMGB-1, which improved the systemic hypotension, pulmonary hypertension, and blood gases, thereby causing improvement of survival time in a progressive neonatal sepsis CLP model.
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