ArticleDigestive diseases and sciences2011
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- Intestinal Alkaline Phosphatase Alleviates Ruminal Acidosis in Dairy Cows Fed High-Concentrate Diets Improves Their Overall Health.Journal of animal physiology and animal nutrition · 2026Article
- Alleviating Clostridium perfringens-Induced Gut Lesionsin Broiler Chickens by Orally Administered Bovine Intestinal Alkaline Phosphatase.Probiotics and antimicrobial proteins · 2026Article
- Intestinal Alkaline Phosphatase Expression in Response toAnimals : an open access journal from MDPI · 2025Article
- recAP administration ameliorates sepsis outcomes through modulation of gut and liver inflammation.Biochemical and biophysical research communications · 2024Article
- Effects of dietary supplementation with medicinal plant mixtures and immunostimulants on the immune response, antioxidant capacity, and hepatopancreatic health of Chinese mitten crab (Frontiers in immunology · 2024Article
- Protective Effect of Alkaline Phosphatase Supplementation on Infant Health.Foods (Basel, Switzerland) · 2022Review
- Connection between Periodontitis-Induced Low-Grade Endotoxemia and Systemic Diseases: Neutrophils as Protagonists and Targets.International journal of molecular sciences · 2021Review
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- Potassium phosphate and potassium carbonate administration by feed or drinking water improved broiler performance, bone strength, digestive phosphatase activity and phosphorus digestibility under induced heat stress conditions.Tropical animal health and production · 2020Article
- Lower expression of endogenous intestinal alkaline phosphatase may predict worse prognosis in patients with Crohn's disease.BMC gastroenterology · 2018Article
- Long-term feeding with high plant protein based diets in gilthead seabream (Sparus aurata, L.) leads to changes in the inflammatory and immune related gene expression at intestinal level.BMC veterinary research · 2018Article
- Sequence and functional analysis of intestinal alkaline phosphatase from Lateolabrax maculatus.Fish physiology and biochemistry · 2017Article
- Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice.Digestive diseases and sciences · 2017Article
- The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract.Mediators of inflammation · 2017Review
- Endotoxemia-menace, marker, or mistake?Journal of leukocyte biology · 2016Review
- Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine.Applied and environmental microbiology · 2016Article
- Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.Journal of the American College of Surgeons · 2016Article
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- Intestinal Alkaline Phosphatase: Potential Roles in Promoting Gut Health in Weanling Piglets and Its Modulation by Feed Additives - A Review.Asian-Australasian journal of animal sciences · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsIntestinal alkaline phosphatase (IAP) is a gut mucosal defense factor known to dephosphorylate lipopolysaccharide (LPS); however, the role of IAP in the gut response to luminal bacteria remains poorly defined. We investigated immune responses of wild-type (WT) and IAP-knockout (IAP-KO) mice to LPS and Salmonella typhimurium challenges.
methodsCryostat sectioning and standard indirect immunohistochemical staining for major histocompatibility complex (MHC) class II molecules were performed on liver tissue from WT and IAP-KO mice. WT and IAP-KO mice were orally gavaged with S. typhimurium; bacterial translocation to mesenteric nodes, liver, and spleen was determined by tissue homogenization and plating. In other experiments, WT and IAP-KO mice received intraperitoneal injections of LPS, with subsequent quantification of complete blood counts and serum interleukin (IL)-6 by enzyme-linked immunosorbent assay (ELISA). WT and IAP-KO whole blood were plated and stimulated with LPS and Pam-3-Cys, followed by cytokine assays.
resultsImmunohistologic liver examinations showed increased expression of MHC class II molecules in IAP-KO mice. Following S. typhimurium challenge, WT mice appeared moribund compared with IAP-KO mice, with increased bacterial translocation. WT mice had >50% decrease (P<.005) in platelets and 1.8-fold (P<.05) increased serum IL-6 compared with IAP-KO mice in response to LPS injections. IAP-KO whole-blood stimulation with LPS and Pam-3-Cys resulted in increased IL-6 and tumor necrosis factor (TNF)-alpha secretion compared with WT.
conclusionsIAP-KO mice exhibit characteristics consistent with local LPS tolerance. Whole-blood response of IAP-KO mice did not reflect systemic tolerance. These data suggest that IAP is a local immunomodulating factor, perhaps regulating LPS-toll-like receptor 4 (TLR4) interaction between commensal microflora and intestinal epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.