ArticlePlant molecular biology2010
Ovate family protein 1 as a plant Ku70 interacting protein involving in DNA double-strand break repair.
Article in Plant molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- BoOFP6 Negatively Regulates Glucosinolates Accumulation in Broccoli Sprouts by Cytoplasmic Sequestration of BoMYB34-3.Plant, cell & environment · 2026Article
- Better beans: designer TALE-mediated discovery of common bacterial blight resistance.Journal of experimental botany · 2025Article
- Genome-wide identification of the OVATE gene family of proteins in soybean and expression profiling under salt stress.Frontiers in plant science · 2025Article
- Phylogenomic curation of Ovate Family Proteins (OFPs) in the U's Triangle of Brassica L. indicates stress-induced growth modulation.PloS one · 2024Article
- A 4.43-Kb deletion of chromosomal segment containing an ovate family protein confers long capsule in sesame (Sesamum indicum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-wide identification and characterization of OVATE family proteins inFrontiers in plant science · 2022Article
- Genome-wide characterization of ovate family protein gene family associated with number of seeds per silique inFrontiers in plant science · 2022Article
- Identification, Expression, and Interaction Analysis of Ovate Family Proteins inFrontiers in plant science · 2021Article
- Systematic analysis of thePhysiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Genome-wide identification, expression, and interaction analysis for ovate family proteins in peach.Molecular biology reports · 2019Article
- Overexpression ofHorticulture research · 2019Article
- Plant Organ Shapes Are Regulated by Protein Interactions and Associations With Microtubules.Frontiers in plant science · 2018Review
- Overview of OVATE FAMILY PROTEINS, A Novel Class of Plant-Specific Growth Regulators.Frontiers in plant science · 2016Review
- Phylogenetic analyses provide the first insights into the evolution of OVATE family proteins in land plants.Annals of botany · 2014Article
- What lies beyond the eye: the molecular mechanisms regulating tomato fruit weight and shape.Frontiers in plant science · 2014Article
- Mapping of two suppressors of OVATE (sov) loci in tomato.Heredity · 2013Article
- Genome-wide identification, phylogeny and expression analysis of SUN, OFP and YABBY gene family in tomato.Molecular genetics and genomics : MGG · 2013Article
- Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice.The New phytologist · 2012Article
- Multiple evidence for the role of an Ovate-like gene in determining fruit shape in pepper.BMC plant biology · 2011Article
- Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ku heterodimer, a DNA repair protein complex consisting of 70- and 80-kDa subunits, is involved in the non-homologous end-joining (NHEJ) pathway. Plants are thought to use the NHEJ pathway primarily for the repair of DNA double-strand breaks (DSBs). The Ku70/80 protein has been identified in many plants and been shown to possess several similar functions to its counter protein complex in mammals. In the present study, ovate family protein 1 (AtOFP1) was demonstrated to be a plant Ku-interacting protein by yeast two-hybrid screening and the GST pull-down assay. Truncation analysis revealed that the C-terminal domain of AtKu70 contains interacting sites for AtOFP1. The electrophoretic mobility shift assay (EMSA) indicated that AtOFP1 is also a DNA binding protein with its binding domain at the N-terminus. In 3-week-old seedlings, expression of the AtOFP1 gene increased after exposure to DNA-damaging agents (such as methyl methanesulfonate (MMS) and menadione) in a time dependent manner. Seedlings lacking the AtOFP1 protein were more sensitive to MMS and menadione as compared with wild-type. Furthermore, similar to AtKu70(-/-) and AtKu80(-/-), the AtOFP1(-/-) mutant showed relatively lower NHEJ activity in vivo. Taken together, these results suggest that AtOFP1 may play a role in DNA repair through the NHEJ pathway accompanying with the AtKu protein.
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