ArticlePloS one2010
The CC-NB-LRR-type Rdg2a resistance gene confers immunity to the seed-borne barley leaf stripe pathogen in the absence of hypersensitive cell death.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 65 citations in OpenAlex.
- Two atypical resistance proteins confer plant resistance to Melanaphis sorghi in sorghum.Plant communications · 2026Article
- Transcriptome Analysis and Functional Characterization of thePlants (Basel, Switzerland) · 2025Article
- Defining Composition and Function of the Rhizosphere Microbiota of Barley Genotypes Exposed to Growth-Limiting Nitrogen Supplies.mSystems · 2022Article
- Perspectives on plant virus diseases in a climate change scenario of elevated temperatures.Stress biology · 2022Review
- A footprint of plant eco-geographic adaptation on the composition of the barley rhizosphere bacterial microbiota.Scientific reports · 2020Article
- Barley's Second Spring as A Model Organism for Chloroplast Research.Plants (Basel, Switzerland) · 2020Review
- Aegilops umbellulata introgression carrying leaf rust and stripe rust resistance genes Lr76 and Yr70 located to 9.47-Mb region on 5DS telomeric end through a combination of chromosome sorting and sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Lignin-based barrier restricts pathogens to the infection site and confers resistance in plants.The EMBO journal · 2019Article
- A cell death assay in barley and wheat protoplasts for identification and validation of matching pathogen AVR effector and plant NLR immune receptors.Plant methods · 2019Article
- The Coiled-Coil and Nucleotide Binding Domains of BROWN PLANTHOPPER RESISTANCE14 Function in Signaling and Resistance against Planthopper in Rice.The Plant cell · 2017Article
- The tandem repeated organization of NB-LRR genes in the clubroot-resistant CRb locus in Brassica rapa L.Molecular genetics and genomics : MGG · 2017Article
- Marker development using SLAF-seq and whole-genome shotgun strategy to fine-map the semi-dwarf gene ari-e in barley.BMC genomics · 2016Article
- Coexpression network analysis of the genes regulated by two types of resistance responses to powdery mildew in wheat.Scientific reports · 2016Article
- Deciphering the transcriptional regulation and spatiotemporal distribution of immunity response in barley to Pyrenophora graminea fungal invasion.BMC genomics · 2016Article
- Retromer contributes to immunity-associated cell death in Arabidopsis.The Plant cell · 2015Article
- Article
- Inducible expression of p50 from TMV for increased resistance to bacterial crown gall disease in tobacco.Plant molecular biology · 2014Article
- Dominant resistance against plant viruses.Frontiers in plant science · 2014Review
- Validation of doubled haploid plants by enzymatic mismatch cleavage.Plant methods · 2013Article
- Ve1-mediated resistance against Verticillium does not involve a hypersensitive response in Arabidopsis.Molecular plant pathology · 2013Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeaf stripe disease on barley (Hordeum vulgare) is caused by the seed-transmitted hemi-biotrophic fungus Pyrenophora graminea. Race-specific resistance to leaf stripe is controlled by two known Rdg (Resistance to Drechslera graminea) genes: the H. spontaneum-derived Rdg1a and Rdg2a, identified in H. vulgare. The aim of the present work was to isolate the Rdg2a leaf stripe resistance gene, to characterize the Rdg2a locus organization and evolution and to elucidate the histological bases of Rdg2a-based leaf stripe resistance. PRINCIPAL
findingsWe describe here the positional cloning and functional characterization of the leaf stripe resistance gene Rdg2a. At the Rdg2a locus, three sequence-related coiled-coil, nucleotide-binding site, and leucine-rich repeat (CC-NB-LRR) encoding genes were identified. Sequence comparisons suggested that paralogs of this resistance locus evolved through recent gene duplication, and were subjected to frequent sequence exchange. Transformation of the leaf stripe susceptible cv. Golden Promise with two Rdg2a-candidates under the control of their native 5' regulatory sequences identified a member of the CC-NB-LRR gene family that conferred resistance against the Dg2 leaf stripe isolate, against which the Rdg2a-gene is effective. Histological analysis demonstrated that Rdg2a-mediated leaf stripe resistance involves autofluorescing cells and prevents pathogen colonization in the embryos without any detectable hypersensitive cell death response, supporting a cell wall reinforcement-based resistance mechanism.
conclusionsThis work reports about the cloning of a resistance gene effective against a seed borne disease. We observed that Rdg2a was subjected to diversifying selection which is consistent with a model in which the R gene co-evolves with a pathogen effector(s) gene. We propose that inducible responses giving rise to physical and chemical barriers to infection in the cell walls and intercellular spaces of the barley embryo tissues represent mechanisms by which the CC-NB-LRR-encoding Rdg2a gene mediates resistance to leaf stripe in the absence of hypersensitive cell death.
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