ArticlePloS one2010
Skewed distribution of circulating activated natural killer T (NKT) cells in patients with common variable immunodeficiency disorders (CVID).
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- IgA deficiency reveals a microbiota-dependent pathway to gluten sensitivity.Gut microbes · 2026Article
- Beyond B cells: T and Innate Immune Mechanisms of Autoimmunity in Common Variable Immunodeficiency.Clinical reviews in allergy & immunology · 2026Review
- Glioblastoma-enriched glycosphingolipids modulate the function of human iNKT cells.Neuro-oncology · 2025Article
- Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis.Clinics (Sao Paulo, Brazil) · 2022Article
- Opinion Article: NK Cells in Cutaneous Leishmaniasis: Protection or Damage?Frontiers in immunology · 2022Article
- Infectious Complications Reporting in Common Variable Immunodeficiency: A Systematic Review and Meta-analysis.Oman medical journal · 2020Review
- RP-HPLC-ESI-IT Mass Spectrometry Reveals Significant Variations of the Human Salivary Protein Profile Associated with Predominantly Antibody Deficiencies.Journal of clinical immunology · 2020Article
- Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency.Wiener klinische Wochenschrift · 2016Article
- T-cell abnormalities in common variable immunodeficiency: the hidden defect.Journal of clinical pathology · 2016Review
- Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion.Medicine · 2016Article
- Common Variable Immunodeficiency.Indian journal of pediatrics · 2016Review
- Adaptive Memory of Human NK-like CD8Frontiers in immunology · 2016Review
- A Clinical and Laboratory Approach to the Evaluation of Innate Immunity in Pediatric CVID Patients.Frontiers in immunology · 2015Article
- Role of Innate T Cells in Anti-Bacterial Immunity.Frontiers in immunology · 2015Review
- Defective functions of polymorphonuclear neutrophils in patients with common variable immunodeficiency.Immunologic research · 2014Article
- Persistent Immune Activation in CVID and the Role of IVIg in Its Suppression.Frontiers in immunology · 2014Review
- Article
- Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- IVIg immune reconstitution treatment alleviates the state of persistent immune activation and suppressed CD4 T cell counts in CVID.PloS one · 2013Article
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Common variable immunodeficiency disorder (CVID) is the commonest cause of primary antibody failure in adults and children, and characterized clinically by recurrent bacterial infections and autoimmune manifestations. Several innate immune defects have been described in CVID, but no study has yet investigated the frequency, phenotype or function of the key regulatory cell population, natural killer T (NKT) cells. We measured the frequencies and subsets of NKT cells in patients with CVID and compared these to healthy controls. Our results show a skewing of NKT cell subsets, with CD4+ NKT cells at higher frequencies, and CD8+ NKT cells at lower frequencies. However, these cells were highly activated and expression CD161. The NKT cells had a higher expression of CCR5 and concomitantly expression of CCR5+CD69+CXCR6 suggesting a compensation of the remaining population of NKT cells for rapid effector action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.