ArticleFrontiers in neural circuits2010
Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
Article in Frontiers in neural circuits, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 80 citations in OpenAlex.
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- Bioengineering strategy to promote CNS nerve growth and regeneration via chronic glutamate signaling.Acta biomaterialia · 2024Article
- Investigation of central pattern generators in the spinal cord of chicken embryos.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia.International journal of molecular sciences · 2023Review
- Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling.International journal of molecular sciences · 2022Article
- Repetitive optogenetic stimulation of glutamatergic neurons: An alternative to NMDA treatment for generating locomotor activity in spinalized zebrafish larvae.Physiological reports · 2021Article
- Recent Insights into the Rhythmogenic Core of the Locomotor CPG.International journal of molecular sciences · 2021Review
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- The M-current works in tandem with the persistent sodium current to set the speed of locomotion.PLoS biology · 2020Article
- Glutamate receptor subtypes differentially contribute to optogenetically activated swimming in spinally transected zebrafish larvae.Journal of neurophysiology · 2019Article
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- Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury.The Journal of physiology · 2018Article
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
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- Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.Journal of neurophysiology · 2017Article
- Nonlinear Modulation of Cutaneous Reflexes with Increasing Speed of Locomotion in Spinal Cats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Speed dependency in α-motoneuron activity and locomotor modules in human locomotion: indirect evidence for phylogenetically conserved spinal circuits.Proceedings. Biological sciences · 2017Article
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- Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Locomotion is a fundamental motor act that, to a large degree, is controlled by central pattern-generating (CPG) networks in the spinal cord. Glutamate is thought to be responsible for most of the excitatory input to and the excitatory activity within the locomotor CPG. However, previous studies in mammals have produced conflicting results regarding the necessity and role of the different ionotropic glutamate receptors (GluRs) in the CPG function. Here, we use electrophysiological and pharmacological techniques in the in vitro neonatal mouse lumbar spinal cord to investigate the role of a broad range of ionotropic GluRs in the control of locomotor speed and intrinsic locomotor network function. We show that non-NMDA (non-NMDARs) and NMDA receptor (NMDAR) systems may independently mediate locomotor-like activity and that these receptors set different speeds of locomotor-like activity through mechanisms acting at various network levels. AMPA and kainate receptors are necessary for generating the highest locomotor frequencies. For coordination, NMDARs are more important than non-NMDARs for conveying the rhythmic signal from the network to the motor neurons during long-lasting and steady locomotor activity. This study reveals that a diversity of ionotropic GluRs tunes the network to perform at different locomotor speeds and provides multiple levels for potential regulation and plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.