ArticleJournal of clinical microbiology2010
Mass spectrometry biotyper system identifies enteric bacterial pathogens directly from colonies grown on selective stool culture media.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Spectral Precision: Recent Advances in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Pathogen Detection and Resistance Profiling.Microorganisms · 2025Review
- Bacteriological Identification, Characterization and Changes of Feces Microbiome in Prostate Cancer Patients Undergoing Radiotherapy.Cancer management and research · 2025Article
- Foodborne Infections andVaccines · 2024Review
- Expanding the Spectrum of Diseases and Disease Associations Caused byMicroorganisms · 2024Review
- Comparison of MALDI-TOF mass spectrometry and 16S rDNA sequencing for identification of environmental bacteria: a case study of cave mussel-associated culturable microorganisms.Environmental science and pollution research international · 2024Article
- ExploringJournal of mass spectrometry and advances in the clinical lab · 2023Article
- Mass spectrometry-based proteomics as an emerging tool in clinical laboratories.Clinical proteomics · 2023Review
- FromACS omega · 2023Review
- [Shigellosis attended in the emergency department of a regional hospital in southeastern Spain: from their presence to multiresistance].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Pseudotargeted Metabolomic Fingerprinting and Deep Learning for Identification and Visualization of Common Pathogens.Frontiers in microbiology · 2022Article
- Current Scenario and Challenges in the Direct Identification of Microorganisms Using MALDI TOF MS.Microorganisms · 2021Review
- Evaluation of three sample preparation methods for the identification of clinical strains by using two MALDI-TOF MS systems.Journal of mass spectrometry : JMS · 2021Article
- Characterization of OralFrontiers in microbiology · 2021Article
- Identification of Microorganisms by Liquid Chromatography-Mass Spectrometry (LC-MSMolecular & cellular proteomics : MCP · 2020Article
- Review
- Fast and Accurate Bacterial Species Identification in Urine Specimens Using LC-MS/MS Mass Spectrometry and Machine Learning.Molecular & cellular proteomics : MCP · 2019Article
- Identification of Pathogenic Bacteria from Public Libraries via Proteomics Analysis.International journal of environmental research and public health · 2019Article
- Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae.Clinical microbiology reviews · 2019Review
- Evaluation of the Accelerate Pheno System: Results from Two Academic Medical Centers.Journal of clinical microbiology · 2018Article
- Gut Microbiota Colonization and Transmission in the Burying Beetle Nicrophorus vespilloides throughout Development.Applied and environmental microbiology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the performance and cost-effectiveness of a matrix-assisted laser desorption ionization time-of-flight mass spectrometry-based Biotyper system for the routine identification of common enteric bacterial pathogens seen in middle Tennessee from suspicious colonies grown on selective stool culture media. A total of 304 suspicious colonies were selected and further identified from 605 stool specimens. The suspicious colonies were analyzed by the Biotyper system, and the results were compared to those from routine phenotypic methods, which identified 22 Salmonella species, 39 Shigella species, 3 enterohemorrhagic Escherichia coli (EHEC) isolates, 2 Yersinia enterocolitica isolates, 2 Campylobacter species, and 236 gastrointestinal normal flora isolates. The Biotyper system correctly identified the Salmonella species, Yersinia enterocolitica, and Campylobacter species but failed to distinguish the Shigella species and EHEC isolates from E. coli. Among the 236 normal flora isolates, 233 (98.7%) and 228 (96.6%) agreed at the genus and species levels, respectively, between the phenotypic and Biotyper methods. Organism identification scores were insignificantly different between colonies directly from selective media and subsequently from pure subculture. The entire Biotyper identification procedure, from smear preparation to final result reporting, can be completed within 30 min. The Biotyper system provides a rapid and simple screening tool for identifying many, but not all, suspicious colonies grown on selective media within 24 h after inoculation, which shortens test turnaround time by 2 to 3 days.
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