ArticleJournal of clinical microbiology2010
Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Emerging Corynebacterium diphtheriae ST-212 cluster with truncated tox gene linked by possible sexual transmission.Infection · 2026Article
- Detection and diphtheria toxin status of Corynebacterium ulcerans in canine and feline clinical specimens in Japan.The Journal of veterinary medical science · 2026Article
- The emergence and spread of a novel sequence type of Corynebacterium diphtheriae in Vietnam.Scientific reports · 2026Article
- Complete genome of aMicrobiology resource announcements · 2026Article
- A large number of variants ofPeerJ · 2026Article
- Life Identification Number (LIN) codes for the genomic taxonomy of Corynebacterium diphtheriae strains.Genome medicine · 2025Article
- A case of fatal respiratory diphtheria imported from Poland to Germany: possible link to an undetected imported diphtheria cluster in Poland?Infection · 2025Article
- Population structure and antimicrobial resistance ofMicrobial genomics · 2025Article
- Autochthonous outbreak of respiratory diphtheria caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Article
- Toxigenic Corynebacterium ulcerans in raw milk of a cow with acute mastitis: case report and historical review on milk-transmitted diphtheria.Infection · 2025Review
- Fulminant infective endocarditis with toxin-negativeEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Description of two novelbioRxiv : the preprint server for biology · 2024Article
- Description of Corynebacterium hiratae sp. nov. isolated from a human tissue bone a novel member of Corynebacterium Genus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria.Infectious disorders drug targets · 2024Review
- Emerging Corynebacterium diphtheriae Species Complex Infections, Réunion Island, France, 2015-2020.Emerging infectious diseases · 2023Article
- Article
- Corynebacteria of theMicrobiology spectrum · 2023Article
- Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.Microbiology spectrum · 2023Article
- Corynebacterium guaraldiae sp. nov.: a new species of Corynebacterium from human infections.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
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Abstract
We describe the development of a multilocus sequence typing (MLST) scheme for Corynebacterium diphtheriae, the causative agent of the potentially fatal upper respiratory disease diphtheria. Global changes in diphtheria epidemiology are highlighted by the recent epidemic in the former Soviet Union (FSU) and also by the emergence of nontoxigenic strains causing atypical disease. Although numerous techniques have been developed to characterize C. diphtheriae, their use is hindered by limited portability and, in some instances, poor reproducibility. One hundred fifty isolates from 18 countries and encompassing a period of 50 years were analyzed by multilocus sequence typing (MLST). Strain discrimination was in accordance with previous ribotyping data, and clonal complexes associated with disease outbreaks were clearly identified by MLST. The data produced are portable, reproducible, and unambiguous. The MLST scheme described provides a valuable tool for monitoring and characterizing endemic and epidemic C. diphtheriae strains. Furthermore, multilocus sequence analysis of the nucleotide data reveals two distinct lineages within the population of C. diphtheriae examined, one of which is composed exclusively of biotype belfanti isolates and the other of multiple biotypes.
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