ArticleJournal of immunology (Baltimore, Md. : 1950)2010
IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- IL-21 controls CD8Zoological research · 2026Article
- Regulatory Mechanisms and Reversal of CD8Biology · 2023Review
- STAT3 Role in T-Cell Memory Formation.International journal of molecular sciences · 2022Review
- Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8Immune network · 2021Article
- CD4Cancer science · 2020Article
- Respiratory syncytial virus reduces STAT3 phosphorylation in human memory CD8 T cells stimulated with IL-21.Scientific reports · 2019Article
- IL-21 regulates SOCS1 expression in autoreactive CD8Scientific reports · 2019Article
- Choline acetyltransferase-expressing T cells are required to control chronic viral infection.Science (New York, N.Y.) · 2019Article
- Article
- IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8AIDS research and human retroviruses · 2017Article
- Absence of Grail promotes CD8Nature communications · 2017Article
- Article
- T memory stem cells in health and disease.Nature medicine · 2017Review
- IL-21 Augments Rapamycin in Expansion of Alpha Fetoprotein Antigen Specific Stem-Cell-like Memory T CellsThe Pan African medical journal · 2017Article
- B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.Frontiers in neurology · 2017Article
- IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.Scientific reports · 2016Article
- IL-21 and T Cell Differentiation: Consider the Context.Trends in immunology · 2016Review
- A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.The Journal of clinical investigation · 2015Article
- A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control.Cell reports · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
CD4 T cells are principal producers of IL-21 and are often required for optimal CD8 T cell responses. Therefore, we investigated the importance of IL-21 in determining the phenotypic attributes, functional quality, and maintenance of antiviral CD8 T cells following acute infection with the prototypic mouse pathogen lymphocytic choriomeningitis virus. Previous reports have documented an obligatory role for IL-21 in sustaining CD8 T cell responses during chronic infections. Here we show that the requirements for IL-21 are less stringent following acute infections; however, in the absence of IL-21, the capacity of CD8 T cells to attain the polyfunctional trait of IL-2 production is consistently reduced during both the effector and memory phases. This is further supported by in vitro studies showing that the addition of IL-21 promotes the differentiation of IL-2-producing CD8 T cells. Although the generation of memory CD8 T cells, which are capable of mounting protective recall responses, proceeds independently of IL-21, we demonstrate that IL-21 does function to support secondary responses, especially under competitive conditions. Collectively, these studies highlight the potential roles of IL-21 in determining the quality of CD8 T cell responses postinfection.
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Registered trials
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