ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 79 citations in OpenAlex.
- The Enigmatic Presence of Actin Rings, Actin Cables and Ectopic Hair Cells in the Vestibular Maculae of Mice and Humans.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Cell death modalities modulate inflammatory and regenerative programs in zebrafish sensory organs.Nature communications · 2026Article
- Article
- Anatomical and molecular insights into avian inner ear sensory hair cell regeneration.Developmental biology · 2025Review
- Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review.Journal of otology · 2024Review
- Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation.Frontiers in neurology · 2024Article
- Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells.The Journal of physiology · 2023Article
- Mitochondrial form and function in hair cells.Hearing research · 2023Review
- Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.Frontiers in immunology · 2023Article
- Semi-automated quantification of hair cells in the mature mouse utricle.Hearing research · 2022Article
- Noise exposure levels predict blood levels of the inner ear protein prestin.Scientific reports · 2022Observational
- Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.Frontiers in cellular neuroscience · 2022Article
- Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity.Frontiers in neuroscience · 2022Review
- Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.eLife · 2021Article
- Scar Formation and Debris Elimination during Hair Cell Degeneration in the Adult DTR Mouse.Neuroscience · 2021Article
- Functional Interaction BetweenFrontiers in cellular neuroscience · 2021Article
- Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity.Frontiers in molecular neuroscience · 2021Article
- Cisplatin-induced ototoxicity in organotypic cochlear cultures occurs independent of gap junctional intercellular communication.Cell death & disease · 2020Article
- Exosomes mediate sensory hair cell protection in the inner ear.The Journal of clinical investigation · 2020Article
- Macrophages Respond Rapidly to Ototoxic Injury of Lateral Line Hair Cells but Are Not Required for Hair Cell Regeneration.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Epithelial homeostasis is essential for sensory transduction in the auditory and vestibular organs of the inner ear, but how it is maintained during trauma is poorly understood. To examine potential repair mechanisms, we expressed β-actin-enhanced green fluorescent protein (EGFP) in the chick inner ear and used live-cell imaging to study how sensory epithelia responded during aminoglycoside-induced hair cell trauma. We found that glial-like supporting cells used two independent mechanisms to rapidly eliminate dying hair cells. Supporting cells assembled an actin cable at the luminal surface that extended around the pericuticular junction and constricted to excise the stereocilia bundle and cuticular plate from the hair cell soma. Hair bundle excision could occur within 3 min of actin-cable formation. After bundle excision, typically with a delay of up to 2-3 h, supporting cells engulfed and phagocytosed the remaining bundle-less hair cell. Dual-channel recordings with β-actin-EGFP and vital dyes revealed phagocytosis was concurrent with loss of hair cell integrity. We conclude that supporting cells repaired the epithelial barrier before hair cell plasmalemmal integrity was lost and that supporting cell activity was closely linked to hair cell death. Treatment with the Rho-kinase inhibitor Y-27632 did not prevent bundle excision but prolonged phagocytic engulfment and resulted in hair cell corpses accumulating within the epithelium. Our data show that supporting cells not only maintain epithelial integrity during trauma but suggest they may also be an integral part of the hair cell death process itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.