ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
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Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spinal cord stimulation for Parkinson's disease: a systematic review.Neurosurgical review · 2016Pooled it
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Article
- Network state transitions under deep brain stimulation: A Wilson-Cowan model of Parkinson's Disease.Journal of computational neuroscience · 2026Article
- Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations.PLoS computational biology · 2026Article
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Computational Modeling of Parkinson's Disease Across Scales: From Mechanisms to Biomarkers, Drug Discovery, and Personalized Therapies.Brain sciences · 2026Review
- Timed microglia depletion promotes functional network reorganization and motor recovery after stroke.Brain communications · 2026Article
- Temporal-oscillatory entrainment: a multi-timescale framework for rhythmic coordination from neural to social frequencies.Frontiers in human neuroscience · 2026Article
- Speech Perception and Preparation Are Supported by Distinct Neural Dynamics Across Development.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Can we infer excitation-inhibition balance from the spectrum of population activity?Communications biology · 2025Article
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- Modeling characteristics of neuronal firing in the thalamocortical network of connections in control and parkinsonian primates.Journal of computational neuroscience · 2025Article
- Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.Journal of neural engineering · 2025Article
- Neuronal and network resonance in the external globus pallidus.Journal of neurophysiology · 2025Article
- Delay suppression control of β-oscillations: a proposal for dual-target adaptive deep brain stimulation on STN-GPe network model.Biological cybernetics · 2025Article
- Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.medRxiv : the preprint server for health sciences · 2025Article
- Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.Nature communications · 2025Article
- Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing.Scientific reports · 2025Article
- Pathological beta power increase in the subthalamic nucleus is absent in essential tremor.Brain communications · 2025Article
67 more citing papers are in PubMed but not listed here.
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The advance of Parkinson's disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13-30 Hz). While the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus pars externa (GPe). To investigate this hypothesis, we develop a computational model of the STN-GPe network based upon anatomical and electrophysiological studies. Significantly, our study shows that for certain parameter regimes, the model intrinsically oscillates in the beta range. Through an analytical study of the model, we identify a simple set of necessary conditions on model parameters that guarantees the existence of beta oscillations. These conditions for generation of oscillations are described by a set of simple inequalities and can be summarized as follows: (1) The excitatory connections from STN to GPe and the inhibitory connections from GPe to STN need to be sufficiently strong. (2) The time required by neurons to react to their inputs needs to be short relative to synaptic transmission delays. (3) The excitatory input from the cortex to STN needs to be high relative to the inhibition from striatum to GPe. We confirmed the validity of these conditions via numerical simulation. These conditions describe changes in parameters that are consistent with those expected as a result of the development of Parkinson's disease, and predict manipulations that could inhibit the pathological oscillations.
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