ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area.Frontiers in neuroscience · 2025Article
- EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2023Article
- Claustrum modulates behavioral sensitivity and EEG activity of propofol anesthesia.CNS neuroscience & therapeutics · 2023Article
- A nodal point for brain-state transitions: the mesopontine tegmental anesthesia area (MPTA) in mice.Experimental brain research · 2021Article
- Neurotransmitter networks in mouse prefrontal cortex are reconfigured by isoflurane anesthesia.Journal of neurophysiology · 2020Article
- Acute Exposure to Pacific Ciguatoxin Reduces Electroencephalogram Activity and Disrupts Neurotransmitter Metabolic Pathways in Motor Cortex.Molecular neurobiology · 2017Article
- Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways.The Journal of clinical investigation · 2017Article
- Article
- Brainstem stimulation increases functional connectivity of basal forebrain-paralimbic network in isoflurane-anesthetized rats.Brain connectivity · 2014Article
- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- Brainstem stimulation augments information integration in the cerebral cortex of desflurane-anesthetized rats.Frontiers in integrative neuroscience · 2014Article
- GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.Brain research · 2013Article
- Article
- Sleep and Anesthesia Interactions: A Pharmacological Appraisal.Current anesthesiology reports · 2013Article
- Adenosine A(1) receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release.Anesthesiology · 2013Article
- GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep.Sleep · 2012Article
- Neuropharmacology of Sleep and Wakefulness: 2012 Update.Sleep medicine clinics · 2012Article
- Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex.Sleep · 2012Article
- Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation.Journal of neurochemistry · 2011Article
- Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Drugs that potentiate transmission at GABA(A) receptors are widely used to enhance sleep and to cause general anesthesia. The mechanisms underlying these effects are unknown. This study tested the hypothesis that GABA(A) receptors in the pontine reticular nucleus, oral part (PnO) of mouse modulate five phenotypes of arousal: sleep and wakefulness, cortical electroencephalogram (EEG) activity, acetylcholine (ACh) release in the PnO, breathing, and recovery time from general anesthesia. Microinjections into the PnO of saline (vehicle control), the GABA(A) receptor agonist muscimol, muscimol with the GABA(A) receptor antagonist bicuculline, and bicuculline alone were performed in male C57BL/6J mice (n = 33) implanted with EEG recording electrodes. Muscimol caused a significant increase in wakefulness and decrease in rapid eye movement (REM) and non-REM (NREM) sleep. These effects were reversed by coadministration of bicuculline. Bicuculline administered alone caused a significant decrease in wakefulness and increase in NREM sleep and REM sleep. Muscimol significantly increased EEG power in the delta range (0.5-4 Hz) during wakefulness and in the theta range (4-9 Hz) during REM sleep. Dialysis delivery of bicuculline to the PnO of male mice (n = 18) anesthetized with isoflurane significantly increased ACh release in the PnO, decreased breathing rate, and increased anesthesia recovery time. All drug effects were concentration dependent. The effects on phenotypes of arousal support the conclusion that GABA(A) receptors in the PnO promote wakefulness and suggest that increasing GABAergic transmission in the PnO may be one mechanism underlying the phenomenon of paradoxical behavioral activation by some benzodiazepines.
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