ArticleJournal of virology2010
Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species.PLoS pathogens · 2022Trial
- Viral escape mutations do not account for non-protection from SIVmac239 challenge in RhCMV/SIV vaccinated rhesus macaques.Frontiers in immunology · 2024Article
- Within-host diversity of SARS-CoV-2 lineages and effect of vaccination.Research square · 2022Article
- Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.Nature communications · 2021Article
- Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.Journal of virology · 2018Article
- Universal Target Capture of HIV Sequences From NGS Libraries.Frontiers in microbiology · 2018Article
- A penalized regression approach to haplotype reconstruction of viral populations arising in early HIV/SIV infection.Bioinformatics (Oxford, England) · 2017Article
- Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.AIDS research and human retroviruses · 2017Article
- Article
- Article
- A Pan-HIV Strategy for Complete Genome Sequencing.Journal of clinical microbiology · 2016Article
- Quantifying Next Generation Sequencing Sample Pre-Processing Bias in HIV-1 Complete Genome Sequencing.Viruses · 2016Article
- Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Utility of Metagenomic Next-Generation Sequencing for Characterization of HIV and Human Pegivirus Diversity.PloS one · 2015Article
- Comparison of Major and Minor Viral SNPs Identified through Single Template Sequencing and Pyrosequencing in Acute HIV-1 Infection.PloS one · 2015Article
- Cross-clade simultaneous HIV drug resistance genotyping for reverse transcriptase, protease, and integrase inhibitor mutations by Illumina MiSeq.Retrovirology · 2014Article
- Deep sequencing: becoming a critical tool in clinical virology.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Review
- Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations.Nucleic acids research · 2014Article
- Developing high-throughput HIV incidence assay with pyrosequencing platform.Journal of virology · 2014Article
- Quantitative characterization of defective virus emergence by deep sequencing.Journal of virology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian immunodeficiency virus (HIV/SIV) infection. Minor viral variants have important implications for drug resistance, receptor tropism, and immune evasion. Here, we used ultradeep pyrosequencing to sequence complete HIV/SIV genomes, detecting variants present at a frequency as low as 1%. This approach provides a more complete characterization of the viral population than is possible with conventional methods, revealing low-level drug resistance and detecting previously hidden changes in the viral population. While this work applies pyrosequencing to immunodeficiency viruses, this approach could be applied to virtually any viral pathogen.
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Registered trials
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