ArticleGenes & development2010
Chromatin-dependent binding of the S. cerevisiae HMGB protein Nhp6A affects nucleosome dynamics and transcription.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Genetics · 2026Article
- The role of the Aspergillus nidulans high mobility group B protein HmbA, the orthologue of Saccharomyces cerevisiae Nhp6p.Scientific reports · 2022Article
- Structural Features of the Nucleosomal DNA Modulate the Functional Binding of a Transcription Factor and Productive Transcription.Frontiers in genetics · 2022Article
- Article
- The HMGB chromatin protein Nhp6A can bypass obstacles when traveling on DNA.Nucleic acids research · 2020Article
- High Free-Energy Barrier of 1D Diffusion Along DNA by Architectural DNA-Binding Proteins.Journal of molecular biology · 2018Article
- Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.PLoS genetics · 2018Article
- The mating type locus protein MAT1-2-1 of Trichoderma reesei interacts with Xyr1 and regulates cellulase gene expression in response to light.Scientific reports · 2017Article
- Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions.Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Article
- Deciphering the role of the AT-rich interaction domain and the HMG-box domain of ARID-HMG proteins of Arabidopsis thaliana.Plant molecular biology · 2016Article
- Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.EMBO reports · 2016Article
- Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins.Epigenetics & chromatin · 2016Article
- Microarray experiments and factors which affect their reliability.Biology direct · 2015Review
- Yeast high mobility group protein HMO1 stabilizes chromatin and is evicted during repair of DNA double strand breaks.Nucleic acids research · 2015Article
- Nucleosome remodeling by the SWI/SNF complex is enhanced by yeast high mobility group box (HMGB) proteins.Biochimica et biophysica acta · 2014Article
- Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription.Genes & development · 2014Article
- A network of HMG-box transcription factors regulates sexual cycle in the fungus Podospora anserina.PLoS genetics · 2013Article
- Histone density is maintained during transcription mediated by the chromatin remodeler RSC and histone chaperone NAP1 in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Systematic dissection of roles for chromatin regulators in a yeast stress response.PLoS biology · 2012Article
- In vivo effects of histone H3 depletion on nucleosome occupancy and position in Saccharomyces cerevisiae.PLoS genetics · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
The Saccharomyces cerevisiae protein Nhp6A is a model for the abundant and multifunctional high-mobility group B (HMGB) family of chromatin-associated proteins. Nhp6A binds DNA in vitro without sequence specificity and bends DNA sharply, but its role in chromosome biology is poorly understood. We show by whole-genome chromatin immunoprecipitation (ChIP) and high-resolution whole-genome tiling arrays (ChIP-chip) that Nhp6A is localized to specific regions of chromosomes that include ∼23% of RNA polymerase II promoters. Nhp6A binding functions to stabilize nucleosomes, particularly at the transcription start site of these genes. Both genomic binding and transcript expression studies point to functionally related groups of genes that are bound specifically by Nhp6A and whose transcription is altered by the absence of Nhp6. Genomic analyses of Nhp6A mutants specifically defective in DNA bending reveal a critical role of DNA bending for stabilizing chromatin and coregulation of transcription but not for targeted binding by Nhp6A. We conclude that the chromatin environment, not DNA sequence recognition, localizes Nhp6A binding, and that Nhp6A stabilizes chromatin structure and coregulates transcription.
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