ReviewThe American journal of psychiatry2010
Linking molecules to mood: new insight into the biology of depression.
Review in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
277 citing papers in PubMed, 5 syntheses or guidelines pooled it, 632 citations in OpenAlex.
- Efficacy and tolerability of antidepressants in individuals suffering from physical conditions and depressive disorders: network meta-analysis.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- Association of Thyroid Function with Suicidal Behavior: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Prospective biomarkers of major depressive disorder: a systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis.Molecular neurobiology · 2018Pooled it
- Pooled it
- Validation of the English version of the Mood Rhythm Instrument.BMC psychology · 2020Trial
- A randomized controlled trial of intranasal ketamine in major depressive disorder.Biological psychiatry · 2014Trial
- Nucleus accumbens neuron subtype translatome signatures in socially stressed females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Integrative analysis of single nucleotide polymorphism of PDE7B (rs2327669) with biopsychosocial and biochemical parameters in β-thalassemia major patients in Pakistani Cohort.Molecular biology reports · 2026Article
- TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.Psychopharmacology · 2026Article
- Article
- Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility.Basic & clinical pharmacology & toxicology · 2026Article
- Pan-Cancer Analysis of a Depression-Related Gene Signature Identifies an Immunosuppressive Tumor Microenvironment and Links to Immunotherapy Response in Breast Cancer.Breast cancer (Dove Medical Press) · 2026Article
- Capturing subjective experiences of atypical depression: qualitative investigation of perceived aetiological factors and gender influences.BJPsych open · 2025Article
- Rapid-Onset Therapeutic Effects of Delta Opioid Receptor Agonists on Depression-Like Behaviors Induced by Chronic Social Defeat Stress.Neuropsychopharmacology reports · 2025Article
- Lipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study.BMC psychiatry · 2025Article
- Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function.Frontiers in psychiatry · 2025Article
- Deficiency of vitamin D is associated with antenatal depression: a cross-sectional study.Trends in psychiatry and psychotherapy · 2025Article
- Effects of an acute maximal exercise bout on serum insulin-like growth factor-1 in adults with MDD.Psychoneuroendocrinology · 2025Article
- The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study.Frontiers in public health · 2025Article
217 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder is a heritable psychiatric syndrome that appears to be associated with subtle cellular and molecular alterations in a complex neural network. The affected brain regions display dynamic neuroplastic adaptations to endocrine and immunologic stimuli arising from within and outside the CNS. Depression's clinical and etiological heterogeneity adds a third level of complexity, implicating different pathophysiological mechanisms in different patients with the same DSM diagnosis. Current pharmacological antidepressant treatments improve depressive symptoms through complex mechanisms that are themselves incompletely understood. This review summarizes the current knowledge of the neurobiology of depression by combining insights from human clinical studies and molecular explanations from animal models. The authors provide recommendations for future research, with a focus on translating today's discoveries into improved diagnostic tests and treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.