ArticleDevelopment (Cambridge, England)2010
Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord.bioRxiv : the preprint server for biology · 2025Article
- Article
- Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel-Like Structures in Hydrogels for Tissue Engineering.Journal of the American Heart Association · 2025Article
- Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.The Journal of experimental medicine · 2024Article
- Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis.Frontiers in cell and developmental biology · 2024Article
- A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly.Nature communications · 2023Article
- Origin, form and function of extraembryonic structures in teleost fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- Article
- Integrin intra-heterodimer affinity inversely correlates with integrin activatability.Cell reports · 2021Article
- VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.Experimental cell research · 2019Article
- Article
- Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.PloS one · 2017Article
- Cell collectivity regulation within migrating cell cluster during Kupffer's vesicle formation in zebrafish.Frontiers in cell and developmental biology · 2015Review
- Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions.Biology open · 2014Article
- C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.The Journal of biological chemistry · 2014Article
- Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics.Current biology : CB · 2013Article
- A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.Developmental biology · 2013Review
- Laminin β1a controls distinct steps during the establishment of digestive organ laterality.Development (Cambridge, England) · 2013Article
- Left-right asymmetry in zebrafish.Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Integrin αV can form heterodimers with several β subunits to mediate cell-cell and cell-extracellular matrix interactions. During zebrafish gastrulation, αV is expressed maternally and zygotically. Here, we used a morpholino-mediated αV knockdown strategy to study αV function. Although αV morphants displayed vascular defects, they also exhibited left-right body asymmetry defects affecting multiple visceral organs. This was preceded by mislocalization of dorsal forerunner cells (DFCs) and malformation of the Kupffer's vesicle (KV) laterality organ. These defects were rescued with morpholino-resistant αV mRNA. Like αV, integrin β1b was expressed in DFCs, and β1b knockdown largely recapitulated the laterality phenotype of αV morphants. When tracked in real-time, individual DFCs of both morphants showed defects in DFC migration, preventing them from organizing into a KV of normal shape and size. Thus, we propose that αVβ1b mediates cellular interactions that are necessary for DFC clustering and movements necessary for Kupffer's vesicle formation, uncovering an early contribution of integrins to the regulation of vertebrate laterality.
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