ArticleNucleic acids research2011
Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Characterization and biological health implications of microRNAs from human milk and infant formulas.NPJ science of food · 2025Review
- MicroRNA in neuroexosome as a potential biomarker for HIV-associated neurocognitive disorders.Journal of neurovirology · 2025Article
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects.Biomedicines · 2022Review
- Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway.eLife · 2021Article
- Modulation of miRNAs by vitamin C in H2O2‑exposed human umbilical vein endothelial cells.International journal of molecular medicine · 2020Article
- Epigenetic regulation of intestinal stem cell differentiation.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs.Iranian journal of basic medical sciences · 2020Article
- Dynamics of microRNA expression during mouse prenatal development.Genome research · 2019Article
- MicroRNA-103a regulates sodium-dependent vitamin C transporter-1 expression in intestinal epithelial cells.The Journal of nutritional biochemistry · 2019Article
- Genome-Wide Identification and Transcriptomic Analysis of MicroRNAs Across Various Amphioxus Organs Using Deep Sequencing.Frontiers in genetics · 2019Article
- Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries).PloS one · 2018Article
- Analysis of miR-96 and miR-133a Expression in Gastrointestinal Neuroendocrine Neoplasms.Endocrine pathology · 2017Article
- Characterization of mouse serum exosomal small RNA content: The origins and their roles in modulating inflammatory response.Oncotarget · 2017Article
- Diabetes consequences in the fetus liver of the non-obese diabetic mice.Nutrition & diabetes · 2017Article
- Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs.Nucleic acids research · 2016Article
- MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother.International journal of environmental research and public health · 2015Article
- Predictive value of circulating miR-328 and miR-134 for acute myocardial infarction.Molecular and cellular biochemistry · 2014Article
- MicroRNA-146a and microRNA-155 show tissue-dependent expression in dental pulp, gingival and periodontal ligament fibroblasts in vitro.Journal of oral science · 2014Article
- Circulating miR-208b and miR-34a are associated with left ventricular remodeling after acute myocardial infarction.International journal of molecular sciences · 2014Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
MicroRNAs fine-tune the activity of hundreds of protein-coding genes. The identification of tissue-specific microRNAs and their promoters has been constrained by the limited sensitivity of prior microRNA quantification methods. Here, we determine the entire microRNAome of three endoderm-derived tissues, liver, jejunum and pancreas, using ultra-high throughput sequencing. Although many microRNA genes are expressed at comparable levels, 162 microRNAs exhibited striking tissue-specificity. After mapping the putative promoters for these microRNA genes using H3K4me3 histone occupancy, we analyzed the regulatory modules of 63 microRNAs differentially expressed between liver and jejunum or pancreas. We determined that the same transcriptional regulatory mechanisms govern tissue-specific gene expression of both mRNA and microRNA encoding genes in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.