ArticleBMC genetics2010
Gene cassette transcription in a large integron-associated array.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Adaptative and ancient co-evolution of integrons withMicrobial genomics · 2025Article
- Identification of promoter activity in gene-less cassettes from Vibrionaceae superintegrons.Nucleic acids research · 2024Article
- IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella.Microorganisms · 2022Article
- Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.Microorganisms · 2022Review
- In Silico Detection of Antimicrobial Resistance Integrons inAntibiotics (Basel, Switzerland) · 2021Article
- The Natural History of Integrons.Microorganisms · 2021Review
- Cassette recruitment in the chromosomal Integron of Vibrio cholerae.Nucleic acids research · 2021Article
- Promoter activity of ORF-less gene cassettes isolated from the oral metagenome.Scientific reports · 2019Article
- The antimicrobial resistance crisis: management through gene monitoring.Open biology · 2016Article
- Identification and analysis of integrons and cassette arrays in bacterial genomes.Nucleic acids research · 2016Article
- Dynamics of a Class 1 Integron Located on Plasmid or Chromosome in TwoFrontiers in microbiology · 2016Article
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Bacterial genome instability.Microbiology and molecular biology reviews : MMBR · 2014Review
- The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae.PloS one · 2014Article
- The function of integron-associated gene cassettes in Vibrio species: the tip of the iceberg.Frontiers in microbiology · 2013Review
- Deletion of integron-associated gene cassettes impact on the surface properties of Vibrio rotiferianus DAT722.PloS one · 2013Article
- Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase.Journal of bacteriology · 2012Article
- Integration of a laterally acquired gene into a cell network important for growth in a strain of Vibrio rotiferianus.BMC microbiology · 2011Article
- The influence of the accessory genome on bacterial pathogen evolution.Mobile genetic elements · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe integron/gene cassette system is a diverse and effective adaptive resource for prokaryotes. Short cassette arrays, with less than 10 cassettes adjacent to an integron, provide this resource through the expression of cassette-associated genes by an integron-borne promoter. However, the advantage provided by large arrays containing hundreds of cassettes is less obvious. In this work, using the 116-cassette array of Vibrio sp. DAT722 as a model, we investigated the theory that the majority of genes contained within large cassette arrays are widely expressed by intra-array promoters in addition to the integron-borne promoter.
resultsWe demonstrated that the majority of the cassette-associated genes in the subject array were expressed. We further showed that cassette expression was conditional and that the conditionality varied across the array. We finally showed that this expression was mediated by a diversity of cassette-borne promoters within the array capable of responding to environmental stressors.
conclusionsWidespread expression within large gene cassette arrays could provide an adaptive advantage to the host in proportion to the size of the array. Our findings explained the existence and maintenance of large cassette arrays within many prokaryotes. Further, we suggested that repeated rearrangement of cassettes containing genes and/or promoters within large arrays could result in the assembly of operon-like groups of co-expressed cassettes within an array. These findings add to our understanding of the adaptive repertoire of the integron/gene cassette system in prokaryotes and consequently, the evolutionary impact of this system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.