ArticleMolecular neurodegeneration2010
Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?
Article in Molecular neurodegeneration, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.Annual review of pharmacology and toxicology · 2019Review
- Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.Frontiers in immunology · 2019Article
- Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion.Scientific reports · 2018Article
- Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells.Molecular neurobiology · 2018Article
- Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.PloS one · 2018 · on this mapArticle
- Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia.Current genomics · 2017Article
- Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease.Genome medicine · 2016Article
- The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity.Neurotoxicity research · 2016Article
- Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain.PloS one · 2015Article
- Nuclear receptors in neurodegenerative diseases.Neurobiology of disease · 2014Review
- Role of liver X receptors in cholesterol efflux and inflammatory signaling (review).Molecular medicine reports · 2012Review
- The retinoid X receptors and their ligands.Biochimica et biophysica acta · 2012Review
- Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles.Current Alzheimer research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholesterol content of cerebral membranes is tightly regulated by elaborate mechanisms that balance the level of cholesterol synthesis, uptake and efflux. Among the conventional regulatory elements, a recent research focus has been nuclear receptors, a superfamily of ligand-activated transcription factors providing an indispensable regulatory framework in controlling cholesterol metabolism pathway genes. The mechanism of transcriptional regulation by nuclear receptors such as LXRs involves formation of heterodimers with RXRs. LXR/RXR functions as a sensor of cellular cholesterol concentration and mediates cholesterol efflux by inducing the transcription of key cholesterol shuffling vehicles namely, ATP-binding cassette transporter A1 (ABCA1) and ApoE.
resultsIn the absence of quantitative data from humans, the relevance of expression of nuclear receptors and their involvement in cerebral cholesterol homeostasis has remained elusive. In this work, new evidence is provided from direct analysis of human postmortem brain gene and protein expression suggesting that RXRα, a key regulator of cholesterol metabolism is differentially expressed in individuals with dementia. Importantly, RXRα expression showed strong association with ABCA1 and ApoE gene expression, particularly in AD vulnerable regions.
conclusionsThese findings suggest that LXR/RXR-induced upregulation of ABCA1 and ApoE levels may be the molecular determinants of cholesterol dyshomeostasis and of the accompanying dementia observed in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.