ArticleBMC evolutionary biology2010
Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
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- A Tale of Two Transcriptomic Responses in Agricultural Pests via Host Defenses and Viral Replication.International journal of molecular sciences · 2021Article
- Gene loss through pseudogenization contributes to the ecological diversification of a generalist Roseobacter lineage.The ISME journal · 2021Article
- Glutathione S-transferase: a versatile protein family.3 Biotech · 2020Review
- Diversity of Glutathione S-Transferases (GSTs) in Cyanobacteria with Reference to Their Structures, Substrate Recognition and Catalytic Functions.Microorganisms · 2020Article
- Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular Evolution of the Glutathione S-Transferase Family in the Bemisia tabaci Species Complex.Genome biology and evolution · 2020Article
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- Effects of Iron Oxide Nanoparticles (γ-FeInternational journal of molecular sciences · 2019Article
- Contraction of the ROS Scavenging Enzyme GlutathioneG3 (Bethesda, Md.) · 2019Article
- Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study.Medicina (Kaunas, Lithuania) · 2019Article
- Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis.Journal of molecular medicine (Berlin, Germany) · 2019Review
- Newly validated biomarkers of brain damage may shed light into the role of oxidative stress in the pathophysiology of neurocognitive impairment in dietary restricted phenylketonuria patients.Pediatric research · 2019Review
- Dimethyl Fumarate in the Treatment of Relapsing-Remitting Multiple Sclerosis: Patient Reported Outcomes and Perspectives.Patient related outcome measures · 2019Review
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- Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity.Interdisciplinary toxicology · 2018Review
- Complex evolution of the GSTM gene family involves sharing of GSTM1 deletion polymorphism in humans and chimpanzees.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCytosolic glutathione transferases (cGST) are a large group of ubiquitous enzymes involved in detoxification and are well known for their undesired side effects during chemotherapy. In this work we have performed thorough phylogenetic analyses to understand the various aspects of the evolution and functional diversification of cGSTs. Furthermore, we assessed plausible correlations between gene duplication and substrate specificity of gene paralogs in humans and selected species, notably in mammalian enzymes and their natural substrates.
resultsWe present a molecular phylogeny of cytosolic GSTs that shows that several classes of cGSTs are more ubiquitous and thus have an older ancestry than previously thought. Furthermore, we found that positive selection is implicated in the diversification of cGSTs. The number of duplicate genes per class is generally higher for groups of enzymes that metabolize products of oxidative damage.
conclusions1) Protection against oxidative stress seems to be the major driver of positive selection in mammalian cGSTs, explaining the overall expansion pattern of this subfamily; 2) Given the functional redundancy of GSTs that metabolize xenobiotic chemicals, we would expect the loss of gene duplicates, but by contrast we observed a gene expansion of this family, which likely has been favored by: i) the diversification of endogenous substrates; ii) differential tissue expression; and iii) increased specificity for a particular molecule; 3) The increased availability of sequence data from diversified taxa is likely to continue to improve our understanding of the early origin of the different cGST classes.
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Registered trials
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