Trial reportMolecular pain2010
Nitric oxide is negatively correlated to pain during acute inflammation.
Trial report in Molecular pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of local melatonin application on post-extraction sockets after third molar surgery. A pilot study.Medicina oral, patologia oral y cirugia bucal · 2014Trial
- Physicochemical Characterization and In Vitro Biocompatibility of Epoxy- and Silicone-Based Endodontic Materials.Materials (Basel, Switzerland) · 2026Article
- Does a Single Episode of Pain from Impacted Third Molars Necessitate Their Removal?Journal of maxillofacial and oral surgery · 2024Article
- Proteomic Analysis of Dorsal Root Ganglia in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.bioRxiv : the preprint server for biology · 2024Article
- Proteomic analysis of dorsal root ganglia in a mouse model of paclitaxel-induced neuropathic pain.PloS one · 2024Article
- Exploring scraping therapy: Contemporary views on an ancient healing - A review.Journal of family medicine and primary care · 2021Review
- Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS.Molecules (Basel, Switzerland) · 2021Review
- Protective effect of acacetin on sepsis-induced acute lung injury via its anti-inflammatory and antioxidative activity.Archives of pharmacal research · 2018Article
- High-intensity laser therapy versus pulsed electromagnetic field in the treatment of primary dysmenorrhea.Journal of physical therapy science · 2017Article
- Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain.Inflammopharmacology · 2014Review
- Effects of inducible nitric oxide synthase blockade within the periaqueductal gray on cardiovascular responses during mechanical, heat, and cold nociception.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe role that nitric oxide (NO) plays in modulating pain in the periphery is unclear. We show here, the results of two independent clinical studies (microdialysis and gene expression studies) and a pilot dose finding study (glyceryl trinitrate study), to study the role of NO in the early phase of acute inflammatory pain following oral surgery. The effect of ketorolac on NO production and nitric oxide synthase (NOS) gene expression was also studied.
resultsMicrodialysis samples showed significantly higher levels of NO at the first 100 min compared to the last 80 minutes in the placebo treated group. In the ketorolac group, on the other hand, NO levels gradually decreased over the first 60 min but were similar to placebo over the later 100-180 min, with no significant change in NO level over time. The levels of NO were negatively correlated to pain intensity scores. Local infusion of the NO donor glyceryl trinitrate at the site of surgery, showed a small analgesic effect that did not reach statistical significance in the sample size used. While the gene expression of iNOS and eNOS were not up-regulated, 3 hours after surgery, nNOS was downregulated in both treatment groups and eNOS gene expression was significantly lower in the ketorolac group compared to the placebo group. Further, there was a positive correlation between the change in gene expression of nNOS and eNOS in the placebo group but not in the ketorolac group.
conclusionWe suggest that at this early stage of inflammatory pain in man, NO is analgesic in the periphery. Further, ketorolac down-regulates eNOS gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.