Evidence map›Paper›PMID 20843322›Full record

ArticleVirology journal2010

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

Modou Jobarteh, Marine Malfroy, Ingrid Peterson, Adam Jeng, Ramu Sarge-Njie, Abraham Alabi, Kevin Peterson, Matt Cotten, Andrew Hall, Sarah Rowland-Jones and 4 more

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  18. Human immunodeficiency virus and hepatitis C virus coinfection in Nepal.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Modou JobartehMedical Research Council, Fajara, P O Box 273, Banjul, The Gambia.
Marine Malfroy
Ingrid Peterson
Adam Jeng
Ramu Sarge-Njie
Abraham Alabi
Kevin Peterson
Matt Cotten
Andrew Hall
Sarah Rowland-Jones
Hilton Whittle
Richard Tedder
Assan Jaye
Maimuna Mendy
MRC Unit the Gambia · GMCentre Léon Bérard · FRUnited States Department of Defense · USUniversity of London · GB

Funding

Medical Research Council MC_U190085854Medical Research Council MC_U190088481
6 · The paper itself

Abstract

backgroundThe prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.

objectiveThe aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia.

methodsPlasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA, screened for HCV infection by testing for anti-HCV antibody and HCV RNA.

resultsHBsAg prevalence in HIV-positive individuals is 12.2%. HIV/HBV co-infected individuals with CD4 count of <200 cells µL⁻¹ have a higher HBV DNA viral load than patients with higher CD4 count (log 4.0 vs. log 2.0 DNA copies/ml, p < 0.05). Males (OR = 1.8, 95% CI: 1.0, 3.2) were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9% in HIV-positive individuals.

conclusionThe prevalence of HBsAg carriage in HIV- infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels, indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count.

Indexed as

AdolescentAdultAgedAged, 80 and overCD4 Lymphocyte CountChildChild, PreschoolComorbidityDNA, ViralFemaleGambiaHepatitis BHepatitis B Surface AntigensHepatitis CHepatitis C AntibodiesHIV-1DNA, ViralHepatitis B Surface AntigensHepatitis C AntibodiesRNA, Viral

Identifiers

PMID20843322
PMCPMC2949835
OpenAlexW2112253488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.