ReviewJournal of receptor and signal transduction research2010
Protein tyrosine nitration in cellular signal transduction pathways.
Review in Journal of receptor and signal transduction research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Review
- The Wheat Nitro-Proteome: Protein Nitration Profiles During Drought and Rehydration.Plants (Basel, Switzerland) · 2026Article
- Protein Tyrosine Amination: Detection, Imaging, and Chemoproteomic Profiling with Synthetic Probes.Journal of the American Chemical Society · 2024Article
- An Injectable Dual-Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide.Frontiers in cardiovascular medicine · 2022Article
- Micro RNAs in Regulation of Cellular Redox Homeostasis.International journal of molecular sciences · 2021Review
- Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?Frontiers in endocrinology · 2020Review
- Switchable Nitroproteome States ofFrontiers in microbiology · 2019Article
- Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy.Frontiers in oncology · 2018Review
- Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species.Oncotarget · 2017Article
- Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome.Molecular neurobiology · 2017Review
- PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib].Oncotarget · 2017Article
- PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide.Oncotarget · 2017Article
- Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression.Pigment cell & melanoma research · 2016Article
- Role of nitric oxide in the radiation-induced bystander effect.Redox biology · 2015Review
- Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis.Nature protocols · 2014Article
- Nitric oxide-dependent downregulation of BRCA1 expression promotes genetic instability.Cancer research · 2013Article
- O-GlcNAcylation and oxidation of proteins: is signalling in the cardiovascular system becoming sweeter?Clinical science (London, England : 1979) · 2012Review
- Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease.Journal of amino acids · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
How specificity and reversibility in tyrosine nitration are defined biologically in cellular systems is poorly understood. As more investigations identify proteins involved in cell regulatory pathways in which only a small fraction of that protein pool is modified by nitration to affect cell function, the mechanisms of biological specificity and reversal should come into focus. In this review experimental evidence has been summarized to suggest that tyrosine nitration is a highly selective modification and under certain physiological conditions fulfills the criteria of a physiologically relevant signal. It can be specific, reversible, occurs on a physiological time scale, and, depending on a target, can result in either activation or inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.