ReviewQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2010
Biological pathways and genetic variables involved in pain.
Review in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.PloS one · 2018Trial
- Chronic post-surgical pain in older adults: mechanisms, assessment, and management strategies.Frontiers in medicine · 2025Review
- Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach.Cancers · 2021Article
- Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.Seminars in oncology nursing · 2019Review
- Pain polymorphisms and opioids: An evidence based review.Molecular medicine reports · 2019Article
- The impact of UGT2B7 C802T and CYP3A4*1G polymorphisms on pain relief in cancer patients receiving oxycontin.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.Biological research for nursing · 2017Article
- A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain.Pain research & management · 2017Article
- Genetic variations underlying self-reported physical functioning: a review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Review
- The genetic basis of quality of life in healthy Swedish women: a candidate gene approach.PloS one · 2015Article
- Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014Review
- Biological pathways and genetic mechanisms involved in social functioning.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Article
- Nature and nurture of human pain.Scientifica · 2013Review
- Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.The Journal of clinical investigation · 2012Review
- Conceptual and Analytical Considerations toward the Use of Patient-Reported Outcomes in Personalized Medicine.American health & drug benefits · 2012Review
- Genetic variations and patient-reported quality of life among patients with lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Biomarkers: symptoms, survivorship, and quality of life.Seminars in oncology nursing · 2012Review
- Analgesic-like activity of essential oils constituents.Molecules (Basel, Switzerland) · 2011Review
- Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2010Article
Corrections and comments
- Erratum issuedGeneQOL Consortium [added]; multiple investigator names added
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis paper summarizes current knowledge of pain-related and analgesic-related pathways as well as genetic variations involved in pain perception and management.
methodsThe pain group of the GENEQOL Consortium was given the task of summarizing the current status of research on genetic variations in pain and analgesic efficacy. This review is neither exhaustive nor comprehensive; we focus primarily on single-nucleotide polymorphisms.
resultsTwo categories of potential genetic pain-perception pathways were identified: neurotransmission modulators and mechanisms that affect inflammation. Four categories were identified for analgesic efficacy: genes related to receptor interaction, modulation of opioid effects, metabolism, and transport. Various genetic variations involved in these pathways are proposed as candidate genetic markers for pain perception and for individual sensitivity to analgesics.
conclusionsCandidate gene association studies have been used to provide evidence for the genetic modulation of pain perception and response to analgesics. However, the nature and range of genetic modulation of pain is not well addressed due to the limited number of patients and the limited number of genes and genetic variants investigated in studies to date. Moreover, personalized analgesic treatments will require a more complete understanding of the effects of genetic variants and gene-gene interactions in response to analgesics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.