ArticleJournal of neurology2011
An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis.
Article in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.Oxidative medicine and cellular longevity · 2019Pooled it
- Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis.Scientific reports · 2018Pooled it
- Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis.Journal of neurology · 2014Pooled it
- Serum urate at trial entry and ALS progression in EMPOWER.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2017Trial
- Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles.Annals of neurology · 2026Article
- A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach.International journal of molecular sciences · 2024Review
- Serum Creatinine Protects Against Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study.Molecular neurobiology · 2021Article
- Serum Uric Acid Levels Predict Mortality Risk in Male Amyotrophic Lateral Sclerosis Patients.Frontiers in neurology · 2021Article
- Plasma Uric Acid Helps Predict Cognitive Impairment in Patients With Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2021Article
- Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis.Advances in experimental medicine and biology · 2020Review
- Biomarkers in Motor Neuron Disease: A State of the Art Review.Frontiers in neurology · 2019Review
- Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018Review
- Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Changes in routine laboratory tests and survival in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Targeting urate to reduce oxidative stress in Parkinson disease.Experimental neurology · 2017Review
- ALS biomarkers for therapy development: State of the field and future directions.Muscle & nerve · 2016Review
- Prognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2015Article
- Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Clinical associations between gout and multiple sclerosis, Parkinson's disease and motor neuron disease: record-linkage studies.BMC neurology · 2015Article
- An exploratory study of serum creatinine levels in patients with amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urate is a natural antioxidant, and high serum urate levels could be protective against the development of amyotrophic lateral sclerosis (ALS). To determine if serum urate concentrations were lower in ALS patients than in healthy controls, we compared serum urate levels in 132 ALS patients and 337 age/sex-matched controls. Median urate levels were lower in ALS patients compared to controls (4.2mgl/dL [range:1.4-8.2], vs. 4.7 [1.7-13.1]; p = 0.04). In univariate analysis, high urate levels were less likely to be associated with ALS (odds ratio [OR]: 0.53; 95% CI: 0.29-0.97; p = 0.04), but after adjusting for age, sex and kidney function, the association was not statistically significant (OR: 0.63; 95% CI: 0.32-1.24; p = 0.18). Urate levels were lower in bulbar-onset ALS (3.9 mg/dL), compared to limb-onset ALS (4.3; p = 0.001), and in cases with longer disease duration compared to controls (4.1 mg/dL, vs. 4.7; p = 0.01). In this cross-sectional study, lower levels of serum urate were evident in ALS cases with bulbar-onset and longer disease duration, but were likely to be related to the malnutrition induced by ALS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.