ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review.BMC neuroscience · 2018Pooled it
- Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults.Scientific reports · 2020Trial
- Trial
- Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction.Cerebral circulation - cognition and behavior · 2026Article
- Article
- Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer's disease and mild cognitive impairment patients.Scientific reports · 2025Article
- Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population.Cerebral circulation - cognition and behavior · 2025Article
- COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebrovascular reactivity in Alzheimer's disease signature regions is associated with mild cognitive impairment in adults with hypertension.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Altered Cerebral Vasoreactivity on Transcranial Color-Coded Sonography Related to Akinetic-Rigid Phenotype of Parkinson's Disease: Interim Analysis of a Cross-Sectional Study.Brain sciences · 2023Article
- The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Vascular smooth muscle cell dysfunction in neurodegeneration.Frontiers in neuroscience · 2022Review
- Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.Frontiers in aging neuroscience · 2022Article
- Ultrasonographic Changes in Brain Hemodynamics in Patients with Parkinson's Disease and Risk Factors for Cerebrovascular Disease: A Pilot Study.Parkinson's disease · 2021Article
- Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance.Neurology · 2020Article
- Contributions of Aging to Cerebral Small Vessel Disease.Annual review of physiology · 2020Review
- Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.Frontiers in neurology · 2020Article
- Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.Journal of Alzheimer's disease : JAD · 2020Article
- Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Journal of Alzheimer's disease : JAD · 2020Article
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Authors and funding
12 authors.
Funding
Abstract
Vascular risk factors affect cerebral blood flow (CBF) and cerebral vascular reactivity, contributing to cognitive decline. Hippocampus is vulnerable to both Alzheimer's disease (AD) pathology and ischemia; nonetheless, the information about the impact of vascular risk on hippocampal perfusion is minimal. Cognitively, healthy elderly (NL=18, 69.9±6.7 years) and subjects with mild cognitive impairment (MCI=15, 74.9±8.1 years) were evaluated for the Framingham cardiovascular risk profile (FCRP). All underwent structural imaging and resting CBF assessment with arterial spin labeling (ASL) at 3T magnetic resonance imaging (MRI). In 24 subjects (NL=17, MCI=7), CBF was measured after a carbon dioxide rebreathing challenge. Across all subjects, FCRP negatively correlated with hippocampal (ρ=-0.41, P=0.049) and global cortical (ρ=-0.46, P=0.02) vasoreactivity to hypercapnia (VR(h)). The FCRP-VR(h) relationships were most pronounced in the MCI group: hippocampus (ρ=-0.77, P=0.04); global cortex (ρ=-0.83, P=0.02). The FCRP did not correlate with either volume or resting CBF. The hippocampal VR(h) was lower in MCI than in NL subjects (Z=-2.0, P=0.047). This difference persisted after age and FCRP correction (F([3,20])=4.6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume.
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