ArticleBritish journal of cancer2010
Mechanism of genotoxicity induced by targeted cytoplasmic irradiation.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Soybean glycinin and β-conglycinin damage the intestinal barrier by triggering oxidative stress and inflammatory response in weaned piglets.European journal of nutrition · 2023Article
- Stimulation of Nuclear Factor (Erythroid-Derived 2)-like 2 Signaling by Nucleus Targeted Irradiation with Proton Microbeam.Biology · 2023Article
- Ultrastructural Analysis of Cancer Cells Treated with the Radiopharmaceutical Radium Dichloride ([Cells · 2023Article
- Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams.Biology · 2022Review
- Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses.Scientific reports · 2021Article
- Revisiting the Radiobiology of Targeted Alpha Therapy.Frontiers in medicine · 2021Review
- Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications.Medicina (Kaunas, Lithuania) · 2019Review
- Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.International journal of molecular sciences · 2019Review
- Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.Cancer science · 2019Article
- Targeted cytoplasmic irradiation and autophagy.Mutation research · 2017Article
- DirectRedox biology · 2017Review
- Cytoplasmic Irradiation Induces Metabolic Shift in Human Small Airway Epithelial Cells via Activation of Pim-1 Kinase.Radiation research · 2017Article
- Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.Oncotarget · 2017Article
- A laser-plasma-produced soft X-ray laser at 89 eV generates DNA double-strand breaks in human cancer cells.Journal of radiation research · 2015Article
- Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.Antioxidants & redox signaling · 2014Review
- Mitochondria regulate DNA damage and genomic instability induced by high LET radiation.Life sciences in space research · 2014Article
- Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission.Cancer research · 2013Article
- Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles.International journal of cancer · 2013Article
- Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells.Radiation research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDirect damage to DNA is generally accepted as the main initiator of mutation and cancer induced by environmental carcinogens or ionising radiation. However, there is accumulating evidence suggesting that extracellular/extranuclear targets may also have a key role in mediating the genotoxic effects of ionising radiation. As the possibility of a particle traversal through the cytoplasm is much higher than through the nuclei in environmental radiation exposure, the contribution to genotoxic damage from cytoplasmic irradiation should not be ignored in radiation risk estimation. Although targeted cytoplasmic irradiation has been shown to induce mutations in mammalian cells, the precise mechanism(s) underlying the mutagenic process is largely unknown.
methodsA microbeam that can target the cytoplasm of cells with high precision was used to study mechanisms involved in mediating the genotoxic effects in irradiated human-hamster hybrid (A(L)) cells.
resultsTargeted cytoplasmic irradiation induces oxidative DNA damages and reactive nitrogen species (RNS) in A(L) cells. Lipid peroxidation, as determined by the induction of 4-hydroxynonenal was enhanced in irradiated cells, which could be suppressed by butylated hydroxyl toluene treatment. Moreover, cytoplasmic irradiation of A(L) cells increased expression of cyclooxygenase-2 (COX-2) and activation of extracellular signal-related kinase (ERK) pathway.
conclusionWe herein proposed a possible signalling pathway involving reactive oxygen/nitrogen species and COX-2 in the cytoplasmic irradiation-induced genotoxicity effect.
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Registered trials
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