ArticleJournal of cell science2010
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- AiScience · 2023Article
- The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis.Development (Cambridge, England) · 2023Article
- Review
- PmAP2-β depletion enhanced activation of the Toll signaling pathway during yellow head virus infection in the black tiger shrimp Penaeus monodon.Scientific reports · 2021Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.Journal of cell science · 2018Article
- Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division.eLife · 2018Article
- A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis.PLoS genetics · 2017Article
- Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary.G3 (Bethesda, Md.) · 2016Article
- Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.Molecular biology of the cell · 2016Article
- Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.PLoS genetics · 2015Article
- PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury.PLoS biology · 2014Article
- JAK/STAT pathway dysregulation in tumors: a Drosophila perspective.Seminars in cell & developmental biology · 2014Review
- Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.Autophagy · 2014Article
- Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.Developmental biology · 2014Article
- Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.Development (Cambridge, England) · 2013Article
- Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.Molecular biology of the cell · 2013Article
- Effect of STAT5 silenced by siRNA on proliferation apoptosis and invasion of esophageal carcinoma cell line Eca-109.Diagnostic pathology · 2013Article
- Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway.BMC genomics · 2012Article
- Endosomal crosstalk: meeting points for signaling pathways.Trends in cell biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Appropriate regulation of signal transduction pathways is essential for normal development and is often disrupted in disease. Therefore, many regulatory mechanisms and feedback loops have evolved to ensure appropriate signalling. One mechanism previously suggested to modulate a range of signal transduction pathways involves the internalisation and destruction of transmembrane receptors by the endocytic trafficking machinery. Strikingly, a recent report has suggested that the endocytic trafficking of the Drosophila JAK-STAT pathway receptor Domeless (Dome) does not act to downregulate pathway activity, but rather is necessary for in vivo signalling. Here, we examine this relationship to address the interaction of Drosophila JAK-STAT pathway signalling and endocytic trafficking. We show that Dome is trafficked through clathrin-mediated endocytosis and a directed RNAi screen identified several components of the endocytic machinery as negative regulators of pathway signalling. We demonstrate that Dome signals both from the plasma membrane and internalised vesicles and show, using knockdown experiments, that endocytic components negatively regulate JAK-STAT signalling in vivo. As such, disruption in endocytic trafficking represents a potent negative regulator of the disease relevant JAK-STAT signalling cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.