ArticleHealth and quality of life outcomes2010
Decreased health-related quality of life in disease-free survivors of differentiated thyroid cancer in Korea.
Article in Health and quality of life outcomes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Pooled it
- Pooled it
- Patient-Reported Quality-of-Life Outcome Measures in the Thyroid Cancer Population.Thyroid : official journal of the American Thyroid Association · 2020Pooled it
- Machine learning-based random forest for predicting decreased quality of life in thyroid cancer patients after thyroidectomy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- Health-related quality of life and predictors in differentiated thyroid cancer patients during the transitional period: A Cross-sectional study.Endocrine · 2026Article
- Allostatic load in thyroid cancer is higher than that of other cancers: A secondary analysis using NHANES.PloS one · 2026Article
- Factors Associated with Sleep Disruption and Fatigue in Thyroid Cancer Survivors.Current oncology (Toronto, Ont.) · 2025Article
- Depression, Anxiety, and Pain Predict Quality of Life in Patients with Differentiated Thyroid Cancer Postradiotherapy Ablation in Taiwan: A 48-Week Follow-Up Study.Current oncology (Toronto, Ont.) · 2024Article
- Long-Term Effect of TIMP3 Gene Expression on Thyroid Cancer: A Cure Model Analysis.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Mental Health and Quality of Life of Patients with Differentiated Thyroid Cancer Pre and Post Radioactive Iodine Treatment: A Prospective Study.Journal of clinical medicine · 2024Article
- Assessment of quality of life in thyroid cancer patients using the EORTC thyroid-specific questionnaire: a prospective cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Status of mental and social activities of young and middle-aged patients after papillary thyroid cancer surgery.Frontiers in oncology · 2024Article
- Observation of changes in quality of life for 5 years after thyroid surgery: an observational cross-sectional study in Korean population.Annals of surgical treatment and research · 2023Article
- Quality of Life in Thyroid Cancer Patients.Cureus · 2023Article
- Reassessing surgical guidelines for papillary thyroid cancer impact on survival: Expanding indications for lobectomy.Surgery · 2023Observational
- Differentiated thyroid cancer: effect on quality of life, depression, and anxiety.Hormones (Athens, Greece) · 2023Article
- Quality of Life of Survivors of Thyroid Cancer Is Not Inferior to That in Subjects without Cancer: Long-Term after Over 5 Years.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Thyroid Cancer-Specific Health-Related Quality of Life Questionnaire: Psychometric Properties of the Persian Version.International journal of preventive medicine · 2022Article
- Health-related quality of life in long-term differentiated thyroid cancer survivors: A cross-sectional Tunisian-based study.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConcern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and to evaluate the important determinants of HRQOL.
methodsThis was a cross-sectional study in which we interviewed consecutive disease-free survivors of DTC. Three different validated questionnaires ("EORTC QLQ-C30" for various functional domains, the "brief fatigue inventory (BFI)" and the "hospital anxiety and depression scale" (HADS)) were used. Data from a large, population based survey of 1,000 people were used as a control.
resultsThe response rate for the questionnaires was 78.9% (316/401). Disease-free survivors of DTC showed a decreased HRQOL in all five functional domains (physical, role, cognitive, emotional, and social) on the EORTC QLQ-C30 compared with controls (P < 0.01). BFI and HADS-anxiety scores also showed greater distress in disease-free survivors of DTC than in controls (P < 0.05). A multiple regression analysis for the determinants of HRQOL showed that the HADS-anxiety, HADS-depression, and BFI scores were the most significant components of decreased HRQOL.
conclusionsAlthough disease-free survivors of DTC are expected to have disease-specific survival comparable to the general population, they experience a significantly decreased HRQOL. Anxiety, depression, and fatigue were the major determinants of the decreased HRQOL. Supportive psychological care should be integrated into the management of long-term survivors of DTC.
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