ArticleVirology journal2010
The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Cardiometabolic Comorbidities in Patients With Chronic Hepatitis B and Impact on Incidence of Liver Complications. A Danish Nationwide Cohort Study.International journal of general medicine · 2025Article
- Correlation analysis of hepatic steatosis and hepatitis B virus: a cross-sectional study.Virology journal · 2024Article
- HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC).BMC medical genomics · 2022Article
- Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants.International journal of hepatology · 2022Article
- High Rates of Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Metabolic and Cardiovascular Comorbidities.Microorganisms · 2021Article
- Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression.International journal of molecular sciences · 2020Review
- Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients.Virology : research and treatment · 2019Article
- Effect of adiponectin-encoding gene ADIPOQ single nucleotide polymorphisms +45 and +276 on serum lipid levels after antiretroviral therapy in Japanese patients with HIV-1-infection.The Journal of international medical research · 2016Article
- Inverse Association of Plasma Level of Glutathione Peroxidase with Liver Fibrosis in Chronic Hepatitis B: Potential Role of Iron.Middle East journal of digestive diseases · 2016Article
- Association between hepatitis B and metabolic syndrome: Current state of the art.World journal of gastroenterology · 2016Review
- Association between metabolic syndrome and its individual components with viral hepatitis B.The American journal of the medical sciences · 2014Article
- Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis.Lipids in health and disease · 2012Review
- The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection.Hepatitis research and treatment · 2012Article
- HBV inhibits apoB production via the suppression of MTP expression.Lipids in health and disease · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe natural history of hepatitis B virus (HBV) is complex and influenced by the level of viral replication and host factors. The hepatoprotective role of high density lipoproteins (HDL) and adiponectin as host factors on HBV persistence is less well understood.
methodsTo investigate correlation between HBV DNA level with clinical parameters in patients with chronic hepatitis B, 92 male subjects with HBV infection without any risk factors for diabetes were enrolled in this study. Age and BMI of the study population were matched and HBV DNA, ALT, tumor necrosis factor alpha (TNF-α), adiponectin and lipid levels was measured.
resultsSerum HBV DNA correlated inversely with serum HDL level (r = -0.23; P = 0.014). The median of log copies/ml for HBV DNA (3.67) was considered as cut off point. Patients with HBV DNA level higher than cut off point had lower adiponectin (8.7 ± 5.3 vs 10.7 ± 4.9 μg/ml p = 0.05). Also, adiponectin had a negative correlation with TNF-α (r = -0.21, P = 0.04) and positive correlations with HDL (r = 0.18, P = 0.043). Multivariate regression models show that serum HDL level is an independent factor to predict serum HBV DNA.
conclusionOur findings showed that higher HBV DNA levels are associated with lower HDL and adiponectin but induced TNF-alpha values.
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Registered trials
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