ArticleBMC genomics2010
Gene signatures in wound tissue as evidenced by molecular profiling in the chick embryo model.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Hormone sensitive lipase ablation promotes bone regeneration.Biochimica et biophysica acta. Molecular basis of disease · 2022Article
- Unveiling how vitrification affects the porcine blastocyst: clues from a transcriptomic study.Journal of animal science and biotechnology · 2022Article
- Bioactive Proteins in Channa striata Promote Wound Healing through Angiogenesis and Cell Proliferation.Protein and peptide letters · 2020Article
- Altered haemodynamics causes aberrations in the epicardium.Journal of anatomy · 2019Article
- Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells.Respiratory research · 2018Article
- Consensus guidelines for the use and interpretation of angiogenesis assays.Angiogenesis · 2018Review
- Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft.Transplantation · 2018Article
- A Network Approach to Wound Healing.Advances in wound care · 2013Article
- Translational Bioinformatics Approaches to Drug Development.Advances in wound care · 2013Review
- Fatty acid-binding proteins and peribronchial angiogenesis in bronchopulmonary dysplasia.American journal of respiratory cell and molecular biology · 2011Article
- Practices in wound healing studies of plants.Evidence-based complementary and alternative medicine : eCAM · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModern functional genomic approaches may help to better understand the molecular events involved in tissue morphogenesis and to identify molecular signatures and pathways. We have recently applied transcriptomic profiling to evidence molecular signatures in the development of the normal chicken chorioallantoic membrane (CAM) and in tumor engrafted on the CAM. We have now extended our studies by performing a transcriptome analysis in the "wound model" of the chicken CAM, which is another relevant model of tissue morphogenesis.
resultsTo induce granulation tissue (GT) formation, we performed wounding of the chicken CAM and compared gene expression to normal CAM at the same stage of development. Matched control samples from the same individual were used. We observed a total of 282 genes up-regulated and 44 genes down-regulated assuming a false-discovery rate at 5% and a fold change > 2. Furthermore, bioinformatics analysis lead to the identification of several categories that are associated to organismal injury, tissue morphology, cellular movement, inflammatory disease, development and immune system. Endothelial cell data filtering leads to the identification of several new genes with an endothelial cell signature.
conclusionsThe chick chorioallantoic wound model allows the identification of gene signatures and pathways involved in GT formation and neoangiogenesis. This may constitute a fertile ground for further studies.
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