ArticleBMC systems biology2010
Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.
Article in BMC systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Modeling Alzheimer's Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling.Brain sciences · 2025Review
- Detecting tipping points of complex diseases by network information entropy.Briefings in bioinformatics · 2024Article
- GraphPath: a graph attention model for molecular stratification with interpretability based on the pathway-pathway interaction network.Bioinformatics (Oxford, England) · 2024Article
- Aligning Cross-Species Interactomes for Studying Complex and Chronic Diseases.Life (Basel, Switzerland) · 2023Article
- CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research.Genome medicine · 2022Article
- Exploring autophagy-related prognostic genes of Alzheimer's disease based on pathway crosstalk analysis.Bosnian journal of basic medical sciences · 2022Article
- Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches.Briefings in bioinformatics · 2021Article
- Metabolomic analysis of animal models of depression.Metabolic brain disease · 2020Article
- Protein-protein interactions underlying the behavioral and psychological symptoms of dementia (BPSD) and Alzheimer's disease.PloS one · 2020Article
- The basis of cellular and regional vulnerability in Alzheimer's disease.Acta neuropathologica · 2019Review
- Analysis of the role of DAMTC in lung adenocarcinoma cells based on the DNA microarrays.Oncology letters · 2019Article
- Multiple Testing of Submatrices of a Precision Matrix with Applications to Identification of Between Pathway Interactions.Journal of the American Statistical Association · 2018Article
- Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders.Advances in pharmacological sciences · 2018Article
- A comprehensive analysis on preservation patterns of gene co-expression networks during Alzheimer's disease progression.BMC bioinformatics · 2017Article
- Three-way interaction model to trace the mechanisms involved in Alzheimer's disease transgenic mice.PloS one · 2017Article
- Toward Personalized Network Biomarkers in Alzheimer's Disease: Computing Individualized Genomic and Protein Crosstalk Maps.Frontiers in aging neuroscience · 2017Article
- Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression.Oncotarget · 2016Article
- Crosstalk between pathways enhances the controllability of signalling networks.IET systems biology · 2016Article
- Whole Brain Imaging with Serial Two-Photon Tomography.Frontiers in neuroanatomy · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's disease (AD) is a major neurodegenerative disorder leading to amnesia, cognitive impairment and dementia in the elderly. Usually this type of lesions results from dysfunctional protein cooperations in the biological pathways. In addition, AD progression is known to occur in different brain regions with particular features. Thus identification and analysis of crosstalk among dysregulated pathways as well as identification of their clusters in various diseased brain regions are expected to provide deep insights into the pathogenetic mechanism.
resultsHere we propose a network-based systems biology approach to detect the crosstalks among AD related pathways, as well as their dysfunctions in the six brain regions of AD patients. Through constructing a network of pathways, the relationships among AD pathway and its neighbor pathways are systematically investigated and visually presented by their intersections. We found that the significance degree of pathways related to the fatal disorders and the pathway overlapping strength can indicate the impacts of these neighbored pathways to AD development. Furthermore, the crosstalks among pathways reveal some evidence that the neighbor pathways of AD pathway closely cooperate and play important tasks in the AD progression.
conclusionsOur study identifies the common and distinct features of the dysfunctional crosstalk of pathways in various AD brain regions. The global pathway crosstalk network and the clusters of relevant pathways of AD provide evidence of cooperativity among pathways for potential pathogenesis of the neuron complex disease.
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