ArticleBritish journal of pharmacology2011
Mechanisms of actions of hydrogen sulphide on rat distal colonic epithelium.
Article in British journal of pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- The gut-bone axis: microbial metabolism and nutritional interventions for bone health.Gut microbes · 2026Review
- Prebiotics as modulators of colonic calcium and magnesium uptake.Acta physiologica (Oxford, England) · 2025Review
- Hydrogen sulfide inhibits CaAmerican journal of physiology. Endocrinology and metabolism · 2019Article
- Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis.Scientific reports · 2017Article
- An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Hypoxia/Reoxygenation Effects on Ion Transport across Rat Colonic Epithelium.Frontiers in physiology · 2016Article
- Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide.Oxidative medicine and cellular longevity · 2016Review
- Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.Scientific reports · 2015Article
- Hydrogen sulfide promotes calcium uptake in larval zebrafish.American journal of physiology. Cell physiology · 2015Article
- Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.Molecules (Basel, Switzerland) · 2015Review
- Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- H2S and its role in redox signaling.Biochimica et biophysica acta · 2014Review
- Hydrogen sulfide regulates Ca(2+) homeostasis mediated by concomitantly produced nitric oxide via a novel synergistic pathway in exocrine pancreas.Antioxidants & redox signaling · 2014Article
- ATP-sensitive K(+) channels in rat colonic epithelium.Pflugers Archiv : European journal of physiology · 2013Article
- Effects of hydrogen sulphide on motility patterns in the rat colon.British journal of pharmacology · 2013Article
- Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.PloS one · 2013Article
- Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.British journal of pharmacology · 2012Article
- The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells.British journal of pharmacology · 2012Article
- Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.British journal of pharmacology · 2012Article
- Modulation of ion transport across rat distal colon by cysteine.Frontiers in physiology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe aim of this study was to clarify the mechanisms by which hydrogen sulphide (H₂S) affects ion secretion across rat distal colonic epithelium. EXPERIMENTAL APPROACH: Changes in short-circuit current induced by the H₂S-donor, sodium hydrosulphide (NaHS; 10 mmol·L⁻¹), were measured in Ussing chambers after permeabilization of the apical membrane with nystatin. Cytosolic Ca²(+) concentration ([Ca²(+)](i)) and Ca²(+) in intracellular stores were measured with fluorescent dyes. Changes in mitochondrial membrane potential were estimated with rhodamine 123. KEY
resultsNaHS had a biphasic effect on overall currents across the basolateral membrane: an initial inhibition followed by a secondary stimulation. Both a scilliroside-sensitive action on the Na(+) -K(+)-ATPase and modulation of glibenclamide-sensitive and tetrapentylammonium-sensitive (i.e. ATP-sensitive and Ca²(+)-dependent) basolateral K(+) channels were involved in this action. Experiments with rhodamine 123 revealed that NaHS induced a hyperpolarization of the mitochondrial membrane. NaHS evoked a biphasic change in [Ca²(+)](i) , an initial decrease followed by a secondary increase, known to be mediated by the release of stored Ca²(+). Initial falls in [Ca²(+)](i) were not mediated by a sequestration of Ca²(+) in intracellular Ca²(+) storing organelles, as the Mag-Fura-2 signal was unaffected by NaHS. Falls in [Ca²(+)](i) were inhibited by 2',4'-dichlorobenzamil, an inhibitor of the Na(+)-Ca²(+)-exchanger, and attenuated in Na(+)-free buffer, suggesting a transient stimulation of Ca²(+) outflow by this transporter, directly demonstrated by Mn²(+) quenching experiments. CONCLUSIONS AND IMPLICATIONS: ATP-sensitive and Ca²(+)-dependent basolateral K(+) conductances, the basolateral Na(+)-K(+)-pump as well as Ca²(+) transporters were involved in the action of H₂S in regulating colonic ion secretion.
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