Evidence map›Paper›PMID 20839968›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2010

Bone disease in HIV infection: a practical review and recommendations for HIV care providers.

Grace A McComsey, Pablo Tebas, Elizabeth Shane, Michael T Yin, E Turner Overton, Jeannie S Huang, Grace M Aldrovandi, Sandra W Cardoso, Jorge L Santana, Todd T Brown

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01295034 (Vitamin D Supplements for HIV-positive Patients on cART), which is not on this map. Cited by 201 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 6 pooled it
26.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01295034 nacompletednot on this mapstarted 2011, after this paper: background citation

Vitamin D Supplements for HIV-positive Patients on cART

TypeinterventionalSponsorAndrea BranchRan2011 to 2015Enrolled62ConditionsHIV-associated Co-morbiditiesArmsconventional vitamin D treatment, tiered/titrated vitamin D dosing
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 6 syntheses or guidelines pooled it, 401 citations in OpenAlex.

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  12. Effects of Emtricitabine/Tenofovir on Bone Mineral Density in HIV-Negative Persons in a Randomized, Double-Blind, Placebo-Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Grace A McComseyDepartment of Pediatrics and Medicine, Case Western Reserve University, Cleveland, Ohio, USA. gam9@case.edu
Pablo Tebas
Elizabeth Shane
Michael T Yin
E Turner Overton
Jeannie S Huang
Grace M Aldrovandi
Sandra W Cardoso
Jorge L Santana
Todd T Brown
Columbia University · USCase Western Reserve University · USFundação Oswaldo Cruz · BRJohns Hopkins Medicine · USSouthern California University for Professional Studies · USUniversity of California, San Diego · USUniversity of Pennsylvania · USUniversity of Puerto Rico System · PRWashington University in St. Louis · US

Funding

Osteoporosis in HIV Infected Postmenopausal WomenR01AI065200 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$6.7M
Idiopathic Osteoporosis in Premenopausal WomenK24AR052665 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHANE, ELIZABETH J · 2005 to 2014
$1.8M
Bone mass and mineral metabolism in HIV+ womenK23AI059884 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YIN, MICHAEL T · 2004 to 2008
$647k
NIAID NIH HHS K23 AI059884NIAID NIH HHS R01 AI065200NIAMS NIH HHS K24 AR052665
6 · The paper itself

Abstract

Low bone mineral density (BMD) is prevalent in human immunodeficiency virus (HIV)-infected subjects. Initiation of antiretroviral therapy is associated with a 2%-6% decrease in BMD over the first 2 years, a decrease that is similar in magnitude to that sustained during the first 2 years of menopause. Recent studies have also described increased fracture rates in the HIV-infected population. The causes of low BMD in individuals with HIV infection appear to be multifactorial and likely represent a complex interaction between HIV infection, traditional osteoporosis risk factors, and antiretroviral-related factors. In this review, we make the point that HIV infection should be considered as a risk factor for bone disease. We recommend screening patients with fragility fractures, all HIV-infected post-menopausal women, and all HIV-infected men ⩾50 years of age. We also discuss the importance of considering secondary causes of osteoporosis. Finally, we discuss treatment of the more severe cases of bone disease, while outlining the caveats and gaps in our knowledge.

Indexed as

AgedAged, 80 and overAnti-HIV AgentsBone DensityBone DiseasesFemaleFractures, BoneHIV InfectionsHumansIncidenceMaleMiddle AgedRisk AssessmentAnti-HIV Agents

Identifiers

PMID20839968
PMCPMC3105903
OpenAlexW2114323760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.