ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2010
Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardship.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Treatment failure definitions for non-purulent skin and soft tissue infections: a systematic review.Infection · 2020Pooled it
- Do Patients with Cellulitis Need to be Hospitalized? A Systematic Review and Meta-analysis of Mortality Rates of Inpatients with Cellulitis.Journal of general internal medicine · 2018Pooled it
- Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections: systematic review, network meta-analysis and cost analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Pooled it
- Single Intravenous Dose of Oritavancin for Treatment of Acute Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: Summary of Safety Analysis from the Phase 3 SOLO Studies.Antimicrobial agents and chemotherapy · 2018Trial
- A Randomized Clinical Trial of Single-Dose Versus Weekly Dalbavancin for Treatment of Acute Bacterial Skin and Skin Structure Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Trial
- Comparing short to standard duration of antibiotic therapy for patients hospitalized with cellulitis (DANCE): study protocol for a randomized controlled trial.BMC infectious diseases · 2014Trial
- Determinants of treatment outcomes among hospitalised patients with skin and soft tissue infections: a prospective observational study.BMJ open · 2026Observational
- Clinical and inflammatory predictors of outpatient treatment failure in uncomplicated skin and soft tissue infections: a prospective multicenter study from Türkiye.BMC infectious diseases · 2025Observational
- Utility of Routine Blood Cultures for Upper Extremity Abscesses.Hand (New York, N.Y.) · 2025Article
- Long-term sustainability of improvements in antibiotic prescribing after implementation of a local guideline for the management of patients hospitalized with skin and soft tissue infection.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Letter to the Editor regarding "Long-term sustainability of improvements in antibiotic prescribing after implementation of a local guideline for the management of patients hospitalized with skin and soft tissue infection" by FrappaAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center.SAGE open medicine · 2025Article
- Article
- Estimating the Burden of Clinically SignificantOpen forum infectious diseases · 2023Article
- Epidemiology and Economic Outcomes Associated with Timely versus Delayed Receipt of Appropriate Antibiotic Therapy among US Patients Hospitalized for Native Septic Arthritis: A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2022Article
- Poly(2-oxazoline)s as Stimuli-Responsive Materials for Biomedical Applications: Recent Developments of Polish Scientists.Polymers · 2022Review
- High Yield of Blood Cultures in the Etiologic Diagnosis of Cellulitis, Erysipelas, and Cutaneous Abscess in Elderly Patients.Open forum infectious diseases · 2022Article
- The bacterial pathogen and resistance spectrum in a dermatological inpatient ward: a six-year, retrospective, epidemiological study.GMS hygiene and infection control · 2022Article
- Diffuse Reflectance Spectroscopy with Infrared Thermography for Accurate Prediction of Cellulitis.JID innovations : skin science from molecules to population health · 2021Article
- Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough complicated skin and soft-tissue infections (SSTIs) are among the most common infections requiring hospitalization, their clinical spectrum, management, and outcomes have not been well described.
methodsWe report a cohort of consecutive adult patients hospitalized for SSTI from 1 January through 31 December 2007 at an academic medical center. Cases meeting inclusion criteria were reviewed and classified as cellulitis, cutaneous abscess, or SSTI with additional complicating factors.
resultsIn total, 322 patients were included; 66 (20%) had cellulitis, 103 (32%) had cutaneous abscess, and 153 (48%) had SSTI with additional complicating factors. Injection drug use, diabetes mellitus, and alcohol abuse were common comorbidities. Serum inflammatory markers were routinely measured and blood cultures and imaging studies were routinely performed in each group. Of 150 patients with a positive culture result for an abscess, deep tissue, or blood, Staphylococcus aureus or streptococci were identified in 145 (97%). Use of antibiotics with broad aerobic gram-negative activity (61%-80% of patients) or anaerobic activity (73%-83% of patients) was frequent in each group. The median duration of therapy for cellulitis, cutaneous abscess, and SSTI with additional complicating factors was 13 (interquartile range [IQR], 10-14), 13 (IQR, 10-16), and 14 (IQR, 11-17) days, respectively. Treatment failure, recurrence, or rehospitalization due to SSTI within 30 days occurred in 12.1%, 4.9%, and 9.2% of patients, respectively.
conclusionsHospitalizations for SSTI were common; more than half were due to cellulitis or cutaneous abscess. Frequent use of potentially unnecessary diagnostic studies, broad-spectrum antibiotic therapy, and prolonged treatment courses in these patients suggest targets for antimicrobial stewardship programs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.