ArticleEuropean journal of histochemistry : EJH2010
Expression of SPANX proteins in normal prostatic tissue and in prostate cancer.
Article in European journal of histochemistry : EJH, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- PARP-1 protein expression in glioblastoma multiforme.European journal of histochemistry : EJH · 2012Trial
- Hypomethylated SPANXA1/A2 promotes the metastasis of head and neck squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2020Article
- Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma.Case reports in gastrointestinal medicine · 2020Article
- Iodine promotes thyroid cancer development via SPANXA1 through the PI3K/AKT signalling pathway.Oncology letters · 2019Article
- Article
- Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue.European journal of histochemistry : EJH · 2013Article
- On the future contents of a small journal of histochemistry.European journal of histochemistry : EJH · 2012Article
- Identifying pathological biomarkers: histochemistry still ranks high in the omics era.European journal of histochemistry : EJH · 2011Article
- Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects.European journal of histochemistry : EJH · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sperm protein associated with the nucleus in the X chromosome (SPANX) gene family encode for proteins that are not only expressed in germ cells, but also in a number of tumors. In addition, SPANX genes map in an interval of the X chromosome (namely, Xq27), which has been found to be associated with familial prostate cancer by linkage analysis. The aim of this study was therefore to evaluate SPANX protein expression in normal prostate tissues and in prostate carcinoma. For this purpose, formalin-fixed and paraffin-embedded sections obtained from 15 normal (at autopsy) donors and 12 men with prostate cancer were analyzed by immunohistochemistry. About 40% of both normal and tumor prostate samples resulted SPANX positive. Signals were exclusively with the nucleus in normal prostate cells, whereas both nuclear and cytoplasmic positivity was observed in tumor cells. In conclusion, these findings showed that SPANX genes are expressed in both normal and tumor prostate gland, but the latter showed a peculiar cytoplasmic staining positivity. This suggests a possible association between SPANX over expression and prostate cancer development. Additional studies are needed to corroborate this hypothesis.
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