ArticleInternational journal of cancer2011
A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging.
Article in International journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice.NMR in biomedicine · 2025Article
- Systems Engineering Approach Towards Sensitive Cellular Fluorine-19 MRI.NMR in biomedicine · 2025Review
- In Vivo MRI Tracking of Tumor Vaccination and Antigen Presentation by Dendritic Cells.Molecular imaging and biology · 2022Review
- Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.Cytotherapy · 2021Review
- Functional Imaging Using Fluorine (Methods in molecular biology (Clifton, N.J.) · 2021Article
- 7-T MRI tracking of mesenchymal stromal cells after lung injection in a rat model.European radiology experimental · 2020Article
- Fluorine-19 Cellular MRI Detection of In Vivo Dendritic Cell Migration and Subsequent Induction of Tumor Antigen-Specific Immunotherapeutic Response.Molecular imaging and biology · 2020Article
- MRI-Tracking of Dental Pulp Stem Cells In Vitro and In Vivo Using Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles.Journal of clinical medicine · 2019Article
- A Trimodal Imaging Platform for Tracking Viable Transplanted Pancreatic Islets In Vivo: F-19 MR, Fluorescence, and Bioluminescence Imaging.Molecular imaging and biology · 2019Article
- In vivoMagma (New York, N.Y.) · 2019Article
- Theranostic Nanoparticles for Tracking and Monitoring Disease State.SLAS technology · 2018Review
- Article
- Proceedings: Regenerative Medicine for Lung Diseases: A CIRM Workshop Report.Stem cells translational medicine · 2017Article
- In vitro labelling and detection of mesenchymal stromal cells: a comparison between magnetic resonance imaging of iron-labelled cells and magnetic resonance spectroscopy of fluorine-labelled cells.European radiology experimental · 2017Article
- (19)F-MRI for monitoring human NK cells in vivo.Oncoimmunology · 2016Article
- A bisphosphonate forJournal of fluorine chemistry · 2016Article
- Siloxane Nanoprobes for Labeling and Dual Modality Functional Imaging of Neural Stem Cells.Annals of biomedical engineering · 2016Article
- Recent Advances inEngineering (Beijing, China) · 2015Article
- Nanoparticles and clinically applicable cell tracking.The British journal of radiology · 2015Review
- Cell tracking using (19)F magnetic resonance imaging: technical aspects and challenges towards clinical applications.European radiology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Monitoring of cell therapeutics in vivo is of major importance to estimate its efficacy. Here, we present a novel intracellular label for (19)F magnetic resonance imaging (MRI)-based cell tracking, which allows for noninvasive, longitudinal cell tracking without the use of radioisotopes. A key advantage of (19)F MRI is that it allows for absolute quantification of cell numbers directly from the MRI data. The (19)F label was tested in primary human monocyte-derived dendritic cells. These cells took up label effectively, resulting in a labeling of 1.7 ± 0.1 × 10(13) (19)F atoms per cell, with a viability of 80 ± 6%, without the need for electroporation or transfection agents. This results in a minimum detection sensitivity of about 2,000 cells/voxel at 7 T, comparable with gadolinium-labeled cells. Comparison of the detection sensitivity of cells labeled with (19)F, iron oxide and gadolinium over typical tissue background showed that unambiguous detection of the (19)F-labeled cells was simpler than with the contrast agents. The effect of the (19)F agent on cell function was minimal in the context of cell-based vaccines. From these data, we calculate that detection of 30,000 cells in vivo at 3 T with a reasonable signal to noise ratio for (19)F images would require less than 30 min with a conventional fast spin echo sequence, given a coil similar to the one used in this study. This is well within acceptable limits for clinical studies, and thus, we conclude that (19)F MRI for quantitative cell tracking in a clinical setting has great potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.