ArticleAAPS PharmSciTech2010
Design and in vitro evaluation of capsaicin transdermal controlled release cubic phase gels.
Article in AAPS PharmSciTech, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Mesogenic Architectures for Advanced Drug Delivery: Interrogating Lyotropic and Thermotropic Liquid Crystals.AAPS PharmSciTech · 2024Review
- Recent Progress in Gels for Neuropathic Pain.Gels (Basel, Switzerland) · 2023Review
- Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems.Pharmaceutics · 2023Review
- Transdermal Delivery of Capsaicin Nanoemulgel: Optimization, Skin Permeation andAdvanced pharmaceutical bulletin · 2022Article
- Development and optimization of nanoparticles loaded with erucin, a dietary isothiocyanate isolated fromFrontiers in pharmacology · 2022Article
- Ocular lamellar crystalline gels for sustained release and enhanced permeation of resveratrol against corneal neovascularization.Drug delivery · 2021Article
- Article
- Evaluation of In Vitro Capsaicin Release and Antimicrobial Properties of Topical Pharmaceutical Formulation.Biomolecules · 2021Article
- Preparation and Evaluation of Cubosomes/Cubosomal Gels for Ocular Delivery of Beclomethasone Dipropionate for Management of Uveitis.Pharmaceutical research · 2020Article
- Transdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma.Drug delivery · 2019Article
- Mathematical Modeling of Release Kinetics from Supramolecular Drug Delivery Systems.Pharmaceutics · 2019Review
- Nanostructured liquid crystalline formulation as a remarkable new drug delivery system of anti-epileptic drugs for treating children patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Development of a HPLC Method for the Quantitative Determination of Capsaicin in Collagen Sponge.International journal of analytical chemistry · 2015Article
- Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin.Drug design, development and therapy · 2015Article
- Bioavailability of capsaicin and its implications for drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Cubic and hexagonal liquid crystals as drug delivery systems.BioMed research international · 2014Review
- Cubic phase nanoparticles for sustained release of ibuprofen: formulation, characterization, and enhanced bioavailability study.International journal of nanomedicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO-PG-water system, and their internal structures were confirmed by polarizing light microscopy (PLM) and small-angle X-ray scattering (SAXS). Release results showed the cubic phase gels could provide a sustained system for capsaicin, while the initial water content in the gels was the major factor affecting the release rate. Release kinetics was determined to fit Higuchi's square-root equation indicating that the release was under diffusion control. The calculated diffusion exponent showed the release from cubic phase gels was anomalous transport. The unique structure of the cubic phases, capsaicin distributed in the lipid bilayers, and cubic phase gel swelling contributed to the release mechanism. The cubic phase gel may be an interesting application for transdermal delivery system of capsaicin in alleviating the post-incision pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.