ReviewHeart failure reviews2012
Significance of hyponatremia in heart failure.
Review in Heart failure reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vasopressin receptor antagonists for the treatment of heart failure: a systematic review and meta-analysis of randomized controlled trials.International urology and nephrology · 2015Pooled it
- Community-AcquiredPathogens (Basel, Switzerland) · 2025Article
- Implication of modified MELD scores for postdischarge prognosis in hospitalized patients with heart failure.Heart and vessels · 2023Article
- Association between serum sodium level trajectories and survival in patients with heart failure.ESC heart failure · 2023Article
- The impact of chronic pre-dialysis hyponatremia on clinical outcomes in maintenance hemodialysis patients.International urology and nephrology · 2022Article
- Hyponatremia is associated with more severe biliary disease.World journal of gastrointestinal surgery · 2020Article
- Prognostic Significance of Hyponatremia in ST-elevation Myocardial Infarction/Heart Failure Patients.Cureus · 2019Review
- Article
- Hyponatremia in patients hospitalized with heart failure: a condition often overlooked in low-income settings.International journal of general medicine · 2016Article
- Modulation of fatty acid metabolism is involved in the alleviation of isoproterenol-induced rat heart failure by fenofibrate.Molecular medicine reports · 2015Article
- Peritoneal Dialysis for Heart Failure.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2015Review
- Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure.BMC cardiovascular disorders · 2015Observational
- Hyponatremia Predicts New-Onset Cardiovascular Events in Peritoneal Dialysis Patients.PloS one · 2015Article
- Phylogenetically driven sequencing of extremely halophilic archaea reveals strategies for static and dynamic osmo-response.PLoS genetics · 2014Article
- Synthesis and biological evaluation of substituted desloratadines as potent arginine vasopressin V2 receptor antagonists.Molecules (Basel, Switzerland) · 2014Article
- Hyponatremia in patients with heart failure.World journal of cardiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure is one of the most common, costly, disabling and growing diseases (McMurray and Pfeffer in Lancet 365(9474):1877-1889, 2005). Hyponatremia, conventionally defined as a serum-sodium concentration equal or less than 135 mmol/l (American Heart Association in Heart disease and stroke statistics--2007 update. American Heart Association, Dallas, 2007; Stewart et al. in Eur J Heart Fail 4:361-371, 2002), is a common phenomenon in patients with heart failure, with an incidence of 20-25% (Krumholz et al. in Arch Intern Med 157:e99-e104, 1997; Rosamond et al. in Circulation 117(4):e25-e146, 2008; Adrogue and Madias in N Engl J Med 342:1581-1589, 2000) and seems to be of prognostic importance in patients with heart failure (Luca et al. in Am J Cardiol 96:19L-23L, 2005; Gheorghiade et al. in Eur Heart J 28:980-988, 2007; Gheorghiade et al. in Arch Intern Med 167:1998-2005, 2007). So far treatment strategies have been limited and burdened by side effects. The development of hyponatremia in the setting of heart failure is related to the arginine vasopressin (AVP) dysregulation. Thus, AVP receptor antagonists are a promising approach to treatment. However, several questions remain: whether there is a cause-and-effect mechanism, if the correction of hyponatremia improves outcomes, and defining the specific cut-off level of serum-sodium that should be used to define hyponatremia. In this review, we aim to summarize the literature on hyponatremia in patients with heart failure within several aspects: incidence in clinical trials and registries, prognostic value, underlying mechanisms, therapeutic options, and possible future perspectives.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.