ArticleJournal of computational neuroscience2011
Two types of independent bursting mechanisms in inspiratory neurons: an integrative model.
Article in Journal of computational neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Noradrenergic neuromodulation produces a NMDAR-dependent network state of respiratory rhythmogenesis in the preBötzinger Complex.bioRxiv : the preprint server for biology · 2026Article
- Studying Synchronization of Neural Oscillators through NMDA-AMPA Receptor interactions.Chaos, solitons, and fractals · 2026Article
- Three-factor learning in spiking neural networks: An overview of methods and trends from a machine learning perspective.Patterns (New York, N.Y.) · 2025Review
- Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.bioRxiv : the preprint server for biology · 2025Article
- Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.Frontiers in cellular neuroscience · 2025Article
- Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator.eLife · 2022Article
- Article
- Influence of Electric Current and Magnetic Flow on Firing Patterns of Pre-Bötzinger Complex Model.Neural plasticity · 2021Article
- Correlation Analysis of Synchronization Type and Degree in Respiratory Neural Network.Computational intelligence and neuroscience · 2021Article
- Dynamics Analysis of Firing Patterns in Pre-Bötzinger Complex Neurons Model.Frontiers in computational neuroscience · 2021Article
- The logic behind neural control of breathing pattern.Scientific reports · 2019Article
- Article
- Soma-axon coupling configurations that enhance neuronal coincidence detection.PLoS computational biology · 2019Article
- Timescales and Mechanisms of Sigh-Like Bursting and Spiking in Models of Rhythmic Respiratory Neurons.Journal of mathematical neuroscience · 2017Article
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Multiple timescale mixed bursting dynamics in a respiratory neuron model.Journal of computational neuroscience · 2016Article
- Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network.eLife · 2016Article
- Emergent Network Topology within the Respiratory Rhythm-Generating Kernel Evolved In Silico.PloS one · 2016Article
- Robust network oscillations during mammalian respiratory rhythm generation driven by synaptic dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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2 authors.
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Abstract
The network of coupled neurons in the pre-Bötzinger complex (pBC) of the medulla generates a bursting rhythm, which underlies the inspiratory phase of respiration. In some of these neurons, bursting persists even when synaptic coupling in the network is blocked and respiratory rhythmic discharge stops. Bursting in inspiratory neurons has been extensively studied, and two classes of bursting neurons have been identified, with bursting mechanism depends on either persistent sodium current or changes in intracellular Ca(2+), respectively. Motivated by experimental evidence from these intrinsically bursting neurons, we present a two-compartment mathematical model of an isolated pBC neuron with two independent bursting mechanisms. Bursting in the somatic compartment is modeled via inactivation of a persistent sodium current, whereas bursting in the dendritic compartment relies on Ca(2+) oscillations, which are determined by the neuromodulatory tone. The model explains a number of conflicting experimental results and is able to generate a robust bursting rhythm, over a large range of parameters, with a frequency adjusted by neuromodulators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.