ArticlePLoS genetics2010
Long- and short-term selective forces on malaria parasite genomes.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Genome-Wide Analysis of the Malaria ParasiteFrontiers in immunology · 2020Trial
- Candidates for Balancing Selection in Leishmania donovani Complex Parasites.Genome biology and evolution · 2021Article
- Diagnosing the drug resistance signature inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Review
- Genome-Wide Association Analysis Identifies a Genetic Basis of Infectivity in a Model Bacterial Pathogen.Molecular biology and evolution · 2020Article
- Host-parasite co-evolution and its genomic signature.Nature reviews. Genetics · 2020Review
- Article
- Whole-genome sequencing and analysis of Plasmodium falciparum isolates from China-Myanmar border area.Infectious diseases of poverty · 2018Article
- The polyphyly ofRoyal Society open science · 2018Article
- A Gene-Based Positive Selection Detection Approach to Identify Vaccine Candidates UsingFrontiers in genetics · 2018Article
- Genome-wide scans for the identification of Plasmodium vivax genes under positive selection.Malaria journal · 2017Article
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- Whole Genome Sequencing of Field Isolates Reveals Extensive Genetic Diversity in Plasmodium vivax from Colombia.PLoS neglected tropical diseases · 2015Article
- Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum.BMC genomics · 2013Article
- A population genomics perspective on the emergence and adaptation of new plant pathogens in agro-ecosystems.PLoS pathogens · 2012Article
- Candidate targets of balancing selection in the genome of Staphylococcus aureus.Molecular biology and evolution · 2012Article
- Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.PLoS genetics · 2012Article
- Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.Genome research · 2011Article
- Increased polymorphism near low-complexity sequences across the genomes of Plasmodium falciparum isolates.Genome biology and evolution · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ∼23 Mb genomes encoding ∼5200 protein-coding genes. The protein-coding genes comprise about half of these genomes. Although evolutionary processes have a significant impact on malaria control, the selective pressures within Plasmodium genomes are poorly understood, particularly in the non-protein-coding portion of the genome. We use evolutionary methods to describe selective processes in both the coding and non-coding regions of these genomes. Based on genome alignments of seven Plasmodium species, we show that protein-coding, intergenic and intronic regions are all subject to purifying selection and we identify 670 conserved non-genic elements. We then use genome-wide polymorphism data from P. falciparum to describe short-term selective processes in this species and identify some candidate genes for balancing (diversifying) selection. Our analyses suggest that there are many functional elements in the non-genic regions of these genomes and that adaptive evolution has occurred more frequently in the protein-coding regions of the genome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.