ArticleClinical epidemiology2010
Beyond fatigue: Assessing variables associated with sleep problems and use of sleep medications in multiple sclerosis.
Article in Clinical epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Positive Airway Pressure for Fatigue Treatment in Patients With Multiple Sclerosis and Obstructive Sleep Apnea
A Randomized, Placebo-Controlled Study of Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Sleep in multiple sclerosis: a systematic review and meta-analysis of polysomnographic findings.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- Sleep Disturbance and Cognitive Dysfunction in Multiple Sclerosis: a Systematic Review.Current neurology and neuroscience reports · 2018Pooled it
- Challenges and Innovation for Diagnosing and Treatment of Secondary Progressive Multiple Sclerosis.International journal of molecular sciences · 2026Review
- Sleep Disorders and Cognitive Function in Multiple Sclerosis: A Systematic Review of Polysomnographic Studies and Implications for Neurorehabilitation Strategies.Life (Basel, Switzerland) · 2026Review
- Quality of Life, Self-Reported Cognitive Difficulties, and Performance-Based Cognitive Problems in Multiple Sclerosis: What's Sleep Got to Do With It?Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Correlation between fatigue and quality of life among patients with neuromyelitis optica in West China.Frontiers in neurology · 2025Article
- Real-world patterns in remote longitudinal study participation: A study of the Swiss Multiple Sclerosis Registry.PLOS digital health · 2024Article
- A multidimensional approach to sleep health in multiple sclerosis.Multiple sclerosis and related disorders · 2021Article
- Demographic, clinical, and symptomatic correlates of subjective sleep quality in adults with multiple sclerosis.Multiple sclerosis and related disorders · 2021Article
- Sleep Abnormalities in Multiple Sclerosis.Current treatment options in neurology · 2019Review
- In Patients With Multiple Sclerosis, Both Objective and Subjective Sleep, Depression, Fatigue, and Paresthesia Improved After 3 Weeks of Regular Exercise.Frontiers in psychiatry · 2019Article
- Qualitative Experience of Sleep in Individuals With Spinal Cord Injury.OTJR : occupation, participation and health · 2017Article
- Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse.Frontiers in neurology · 2017Review
- Comparison of Sleep Problems in Individuals with Spinal Cord Injury and Multiple Sclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Comparison of self-report sleep measures for individuals with multiple sclerosis and spinal cord injury.Archives of physical medicine and rehabilitation · 2015Article
- Comparing CESD-10, PHQ-9, and PROMIS depression instruments in individuals with multiple sclerosis.Rehabilitation psychology · 2014Article
- Depression and sleep disturbances in patients with multiple sclerosis and correlation with associated fatigue.Journal of neurosciences in rural practice · 2013Article
- Sleep disturbances in patients with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Self-management for people with multiple sclerosis: report from the first international consensus conference, november 15, 2010.International journal of MS care · 2013Article
- Physical activity and depression in middle and older-aged adults with multiple sclerosis.Disability and health journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent research indicates that sleep disturbances are common in persons with multiple sclerosis (MS), though research to date has primarily focused on the relationship between fatigue and sleep. In order to improve treatment of sleep disorders in MS, a better understanding of other factors that contribute to MS sleep disturbance and use of sleep medications in this population is needed.
methodsIndividuals with MS (N = 473) involved in an ongoing self-report survey study were asked to report on use of over-the-counter and prescription sleep medications. Participants completed the Medical Outcomes Study Sleep (MOSS) scale and other common self-report symptom measures. Multiple regression was used to evaluate factors associated with sleep problems and descriptive statistics were generated to examine use of sleep medications.
resultsThe mean score on the MOSS scale was 35.9 (standard deviation, 20.2) and 46.8% of the sample had moderate or severe sleep problems. The majority of participants did not use over-the-counter (78%) or prescription (70%) sleep medications. In a regression model variables statistically significantly associated with sleep problems included depression, nighttime leg cramps, younger age, pain, female sex, fatigue, shorter duration of MS, and nocturia. The model explained 45% of the variance in sleep problems. Of the variance explained, depression accounted for the majority of variance in sleep problems (33%), with other variables explaining significantly less variance.
conclusionsRegression results indicate that fatigue may play a minor role in sleep disturbance in MS and that clinicians should consider the interrelationship between depression and sleep problems when treating either symptom in this population. More research is needed to explore the possibility of under-treatment of sleep disorders in MS and examine the potential effectiveness of nonpharmaceutical treatment options.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.