ReviewDeutsches Arzteblatt international2010
The diagnosis and treatment of acute pulmonary embolism.
Review in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Artificial intelligence in computed tomography imaging for pulmonary embolism: a narrative review from computed tomography pulmonary angiography to non-contrast computed tomography.Quantitative imaging in medicine and surgery · 2026Review
- Pulmonary artery choriocarcinoma mimicking pulmonary thromboembolism: a case report.Translational cancer research · 2024Article
- Mansoor's Self-Report Tool for Cardiovascular Risk Assessment predicts adverse in-hospital events in patients with pulmonary embolism.The clinical respiratory journal · 2023Article
- Perioperative Management of Incidental Pulmonary Embolisms on Trauma CT Scans: A Narrative Review.Cureus · 2023Review
- Evidence-based perioperative diagnosis and management of pulmonary embolism: A systematic review.Annals of medicine and surgery (2012) · 2022Review
- A new machine learning model for predicting severity prognosis in patients with pulmonary embolism: Study protocol from Wenzhou, China.Frontiers in neuroinformatics · 2022Article
- Impact of ED Organization with a Holding Area and a Dedicated Team on the Adherence to International Guidelines for Patients with Acute Pulmonary Embolism: Experience of an Emergency Department Organized in Areas of Intensity of Care.Medicines (Basel, Switzerland) · 2020Article
- Clinical application of the Innovance D-dimer assay in the diagnosis of acute pulmonary thromboembolism.Experimental and therapeutic medicine · 2017Article
- Heart rate in pulmonary embolism.Internal and emergency medicine · 2015Article
- Impact of advanced age on the severity of normotensive pulmonary embolism.Heart and vessels · 2015Article
- Impact of cancer on the effectiveness of cardiac Troponin I to predict right ventricular dysfunction in acute pulmonary embolism.Thoracic cancer · 2015Article
- D-dimer testing for safe exclusion and risk stratification in patients with acute pulmonary embolism in primary care.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- [Inhospital resuscitation : Decisive measures for the outcome].Der Anaesthesist · 2015Review
- Cardiac troponin I for predicting right ventricular dysfunction and intermediate risk in patients with normotensive pulmonary embolism.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2015Article
- Radiological diagnosis in lung disease: factoring treatment options into the choice of diagnostic modality.Deutsches Arzteblatt international · 2014Review
- [Point-of-care testing in preclinical emergency medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Review
- Preparation, characterization and in vitro thrombolytic activity of a novel streptokinase foam.Journal of thrombosis and thrombolysis · 2014Article
- Imaging of acute pulmonary embolism.Emergency radiology · 2013Review
- The diagnosis and treatment of acute pulmonary embolism: Don't forget ventilation-perfusion scintigraphy.Deutsches Arzteblatt international · 2011Article
- The diagnosis and treatment of acute pulmonary embolism: Regulation in Germany is lacking.Deutsches Arzteblatt international · 2011Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary embolism (PE) is a cardiovascular emergency with high morbidity and mortality.
methodsReview of relevant literature retrieved by a selective Medline search, including current guidelines.
resultsHemodynamically unstable patients are considered to have high-risk PE, whereas hemodynamically stable patients are considered to have non-high-risk PE. After classification into one of these two risk groups, patients undergo further diagnostic evaluation for PE according to the appropriate risk-adapted algorithm. Patients who are in cardiogenic shock or have persistent arterial hypotension (high-risk PE) should undergo multidetector computed tomography (MDCT) or echocardiography at once, so that a PE, if present, can be treated immediately by thrombolysis. For hemodynamically stable patients with non-high-risk PE the proper diagnostic strategy is determined by the clinical probability of PE, which can be calculated with the aid of validated scoring systems and is based on both MDCT and D-dimer levels. For further risk stratification in hemodynamically stable patients, tests are performed to detect right ventricular dysfunction or myocardial injury, either of which indicates intermediate-risk PE. In addition to specific therapy, patients with high-risk PE, patients at high risk for hemorrhage and these with severe renal insufficiency should be anticoagulated with unfractionated heparin. All other patients should be treated with low-molecular-weight heparin or fondaparinux. Thereafter, long-term oral anticoagulation with vitamin K antagonists is recommended.
conclusionModern algorithms have considerably simplified the diagnosis and treatment of acute PE. It would be desirable for these algorithms to be rapidly implemented in routine practice, because speedy diagnosis and immediate treatment can lower the morbidity and mortality associated with PE.
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