ArticleJournal of acquired immune deficiency syndromes (1999)2010
Antiretroviral therapy down-regulates innate antiviral response genes in patients with AIDS in sub-saharan Africa.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Early Transcriptomic Signatures of Immune Response Modulation Following Antiretroviral Therapy in HIV-Infected Patients.International journal of molecular sciences · 2025Article
- Molecular Diagnostics ofDiseases (Basel, Switzerland) · 2024Review
- Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis.BMC medical genomics · 2021Article
- STING and cGAS gene expressions were downregulated among HIV-1-infected persons after antiretroviral therapy.Virology journal · 2021Article
- Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Blood and Cerebrospinal Fluid Biomarkers to Treatment Approaches.Life (Basel, Switzerland) · 2021Review
- Signature genes associated with immunological non-responsiveness to anti-retroviral therapy in HIV-1 subtype-c infection.PloS one · 2020Article
- PD-L1 protein expression and copy number gains in HIV-positive locally advanced cervical cancer.Therapeutic advances in medical oncology · 2020Article
- Impact of antiretroviral drugs on PD-L1 expression and copy number gains with clinical outcomes in HIV-positive and -negative locally advanced cervical cancers.Oncology letters · 2019Article
- Article
- Immune Reconstitution Disorders: Spotlight on Interferons.International journal of biomedical investigation · 2019Article
- Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome.Open forum infectious diseases · 2018Article
- APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz.Frontiers in immunology · 2018Article
- Seroprevalence of histoplasmosis in Kampala, Uganda.Medical mycology · 2016Article
- The immunopathogenesis of cryptococcal immune reconstitution inflammatory syndrome: understanding a conundrum.Current opinion in infectious diseases · 2016Review
- Linking Susceptibility to Infectious Diseases to Immune System Abnormalities among HIV-Exposed Uninfected Infants.Frontiers in immunology · 2016Review
- Immune reconstitution disorders in patients with HIV infection: from pathogenesis to prevention and treatment.Current HIV/AIDS reports · 2014Article
- Altered innate immune development in HIV-exposed uninfected infants.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Dynamics of innate immunity are key to chronic immune activation in AIDS.Current opinion in HIV and AIDS · 2012Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveHIV pathogenesis is characterized by destructive imbalances between virus-mediated immune damage, antiviral immune responses, and immune activation. We characterized the effects of successful antiretroviral therapy (ART) to identify the breadth and patterns of HIV-associated gene expression.
methodsIn a prospective observational, longitudinal cohort study of 10 ART-naive Ugandans with AIDS (median 30 CD4/μL), we measured mRNA gene profiles in peripheral blood using Affymetrix U133_Plus2.0 microarrays at 0, 2, 4, 8, and 24 weeks after ART initiation.
resultsWe identified 160 mRNA transcripts that were consistently down-regulated and 48 that were up-regulated after ART at each point over 24 weeks based on linear regression modeling (adjusted P < 0.05), Of these 208 transcripts, approximately half represent heretofore unrecognized ART-responsive genes and one-third have no known function. The down-regulated genes with known function encoded mediators of innate antiviral responses, including antiviral restriction factors, pattern recognition receptors, and interferon response proteins, and mediators of immune activation, cellular proliferation, and apoptosis.
conclusionsBy using ART to block the viral stimulus, we identified transcripts involved in innate antiviral immunity, including antiviral restriction factors and pattern recognition receptors, that were not previously known to be induced by HIV infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.