ArticleCirculation2010
Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation.
Article in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Endothelin-1 and Vasomotor Tone Following Cardioplegic Ischemia/Reperfusion and Cardiopulmonary Bypass.Cells · 2026Review
- Impaired contractile response of human peripheral arterioles to angiotensin II after cardiopulmonary bypass.Surgery · 2025Article
- Microvascular Dysfunction Following Cardioplegic Arrest and Cardiopulmonary Bypass: Impacts of Diabetes and Hypertension.Biomedicines · 2025Review
- Protein kinase C and endothelial dysfunction in select vascular diseases.Frontiers in cardiovascular medicine · 2025Review
- Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction.Frontiers in medicine · 2023Review
- Article
- Skeletal muscle microvasculature response to β-adrenergic stimuli is diminished with cardiac surgery.Surgery · 2020Article
- Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic Myocardium in the Setting of Metabolic Syndrome.Journal of the American Heart Association · 2019Article
- Impaired coronary contraction to phenylephrine after cardioplegic arrest in diabetic patients.The Journal of surgical research · 2018Article
- Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes.Surgery · 2018Article
- Decreased coronary arteriolar response to KMolecular and cellular biochemistry · 2018Article
- Cyclooxygenase 2 contributes to bradykinin-induced microvascular responses in peripheral arterioles after cardiopulmonary bypass.The Journal of surgical research · 2017Article
- Diabetes Upregulation of Cyclooxygenase 2 Contributes to Altered Coronary Reactivity After Cardiac Surgery.The Annals of thoracic surgery · 2017Article
- Diabetes and Cardioplegia.Journal of nature and science · 2017Article
- Microvascular dysfunction in patients with diabetes after cardioplegic arrest and cardiopulmonary bypass.Current opinion in cardiology · 2016Review
- Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis.The Annals of thoracic surgery · 2014Article
- Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus.Circulation · 2013Article
- Article
- Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes.Circulation · 2012Article
- Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.Investigative ophthalmology & visual science · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe investigated the effects of cardiopulmonary bypass (CPB) on the contractile response of human peripheral microvasculature to endothelin-1 (ET-1), examined the role of specific ET receptors and protein kinase C-alpha (PKC-α), and analyzed ET-1-related gene/protein expression in this response. METHODS AND
resultsHuman skeletal muscle arterioles (90 to 180 μm in diameter) were dissected from tissue harvested before and after CPB from 30 patients undergoing cardiac surgery. In vitro contractile response to ET-1 was assessed by videomicroscopy, with and without an endothelin-A (ET-A) receptor antagonist, an endothelin-B (ET-B) antagonist, or a PKC-α inhibitor. The post-CPB contractile response of peripheral arterioles to ET-1 was significantly decreased compared with pre-CPB response. The response to ET-1 was significantly inhibited in the presence of the ET-A antagonist BQ123 but unchanged in the presence of the ET-B receptor antagonist BQ788. Pretreatment with the PKC-α inhibitor safingol reversed ET-1-induced response from contraction to relaxation. The total protein levels of ET-A and ET-B receptors were not altered after CPB. Microarray analysis showed no significant changes in the gene expression of ET receptors, ET-1-related proteins, and protein kinases after CPB.
conclusionsCPB decreases myogenic contractile function of human peripheral arterioles in response to ET-1. The contractile response to ET-1 is through activation of ET-A receptors and PKC-α. CPB has no effects on ET-1-related gene/protein expression. These results provide novel mechanisms of ET-1-induced contraction in the setting of vasomotor dysfunction after cardiac surgery.
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