ArticleThe Journal of cell biology2010
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- The Golgi Apparatus: A Key Player in Innate Immunity.International journal of molecular sciences · 2024Review
- Lipids and Secretory Vesicle Exocytosis.Advances in neurobiology · 2023Article
- Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.International journal of molecular sciences · 2022Article
- MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis.Cell death discovery · 2022Article
- Lipidomic Profiling in Synovial Tissue.Frontiers in medicine · 2022Review
- Broader Insights into Understanding Tumor Necrosis Factor and Neurodegenerative Disease Pathogenesis Infer New Therapeutic Approaches.Journal of Alzheimer's disease : JAD · 2021Review
- The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases.Frontiers in cell and developmental biology · 2021Review
- PI 3-kinase delta enhances axonal PIPEMBO molecular medicine · 2020Article
- PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia.Leukemia · 2020Article
- p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management.International journal of molecular sciences · 2019Review
- TheBiology open · 2019Article
- PI3K class II α regulates δ-opioid receptor export from theMolecular biology of the cell · 2017Article
- Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The PI3Kδ inhibitor idelalisib suppresses liver and lung cellular respiration.International journal of physiology, pathophysiology and pharmacology · 2015Article
- Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking.Frontiers in immunology · 2014Review
- Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells.Frontiers in immunology · 2014Review
- Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.The Journal of biological chemistry · 2013Article
- The many routes of Golgi-dependent trafficking.Histochemistry and cell biology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphoinositide 3-kinase (PI3K) p110 isoforms are membrane lipid kinases classically involved in signal transduction. Lipopolysaccharide (LPS)-activated macrophages constitutively and abundantly secrete proinflammatory cytokines including tumor necrosis factor-α (TNF). Loss of function of the p110δ isoform of PI3K using inhibitors, RNA-mediated knockdown, or genetic inactivation in mice abolishes TNF trafficking and secretion, trapping TNF in tubular carriers at the trans-Golgi network (TGN). Kinase-active p110δ localizes to the Golgi complex in LPS-activated macrophages, and TNF is loaded into p230-labeled tubules, which cannot undergo fission when p110δ is inactivated. Similar blocks in fission of these tubules and in TNF secretion result from inhibition of the guanosine triphosphatase dynamin 2. These findings demonstrate a new function for p110δ as part of the membrane fission machinery required at the TGN for the selective trafficking and secretion of cytokines in macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.