ArticleAntimicrobial agents and chemotherapy2010
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents.Frontiers in chemistry · 2025Review
- The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates.Molecules (Basel, Switzerland) · 2022Review
- Tafenoquine exhibits broad spectrum antifungal activity at clinically relevant concentrationsNew microbes and new infections · 2022Article
- Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles.Molecules (Basel, Switzerland) · 2020Article
- Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs.Molecules (Basel, Switzerland) · 2019Review
- Neolignans isolated from twigs ofThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Evaluation of Parameters Impacting Drug Susceptibility in Intracellular Trypanosoma cruzi Assay Protocols.SLAS discovery : advancing life sciences R & D · 2017Article
- Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes.EXCLI journal · 2016Article
- The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei.Antimicrobial agents and chemotherapy · 2015Article
- Design and synthesis of novel antileishmanial compounds.International journal of medicinal chemistry · 2015Article
- Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.PLoS neglected tropical diseases · 2014Article
- Article
- Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum.Antimicrobial agents and chemotherapy · 2012Article
- Discovery of safe and orally effective 4-aminoquinaldine analogues as apoptotic inducers with activity against experimental visceral leishmaniasis.Antimicrobial agents and chemotherapy · 2012Article
- Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major.Antimicrobial agents and chemotherapy · 2011Article
- Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis.Antimicrobial agents and chemotherapy · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC(50)s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED(50)) values of 1.2 to 3.5 mg/kg for 5 days. Tafenoquine was less active against intracellular Trypanosoma cruzi amastigotes, with an IC(50) of 21.9 μM.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.