SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2010
Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis.
Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 420 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial - Feasibility Pilot
Radiologic and Clinical Outcomes of Augmentation in Fragility Intertrochanteric Hip Fracture Treatment: A Randomized Multicenter Clinical Trial
The Role of Blood Flow Restriction Therapy in the Postop Rehabilitation of Elderly Patients With Hip Fractures: A Randomized Controlled Pilot Study
Who cites it
420 citing papers in PubMed, 9 syntheses or guidelines pooled it, 945 citations in OpenAlex.
- Proximal femoral bionic nail (PFBN) offers comparable functional and clinical outcomes to PFNA and intertan in the treatment of intertrochanteric fractures: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- The impact of COVID-19 on mortality in trauma patients undergoing orthopedic surgery: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2023Pooled it
- Mortality in COVID-19 patients after proximal femur fracture surgery: a systematic review and meta-analysis.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2023Pooled it
- The Impact of COVID-19 on the Prevalence, Mortality, and Associated Risk Factors for Mortality in Patients with Hip Fractures: A Meta-Analysis.Journal of the American Medical Directors Association · 2023Pooled it
- Quality of life in postmenopausal women with osteoporosis: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Pooled it
- Evaluation of Systemwide Improvement Programs to Optimize Time to Surgery for Patients With Hip Fractures: A Systematic Review.JAMA network open · 2022Pooled it
- Simultaneous versus staged bilateral total hip arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Risk factors for postoperative pneumonia in patients undergoing hip fracture surgery: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- Effects of trehalose supplementation on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial.Scientific reports · 2026Trial
- Risk factors for perioperative acute heart failure in older hip fracture patients and establishment of a nomogram predictive model.Journal of orthopaedic surgery and research · 2023Trial
- Spinal Dexamethasone Effect on Cognitive Disorders After Hip Surgery.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2023Trial
- Outcomes and associated factors after InterTAN nailing of geriatric intertrochanteric fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- AI-based Hip Fracture Classification from Pelvic X-ray Images Using a Hybrid PEFT-ViT and XGBoost Model.Journal of imaging informatics in medicine · 2026Article
- In-hospital mortality in hip fracture patients undergoing surgery later than 24 hours post admission might rather reflect the impact of comorbidities and treatment limitations than additional risks imposed by the mere timely delay itself.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Hip Fracture Management in Older Adults in Resource-Constrained Settings: Determinants, Care Pathways, and Outcomes-A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Health economic evaluation of hip fracture care pathways in The Gambia.BMJ global health · 2026Article
- Article
- Waiting time and mortality after hip fracture: findings from a large single-center cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Longer hospital stay but similar one-year mortality and readmission after combined proximal humerus and proximal femur fragility fractures: a Propensity-Score-Matched Cohort Study.Archives of orthopaedic and trauma surgery · 2026Article
360 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines exist for the surgical treatment of hip fracture, but the effect of early surgery on mortality and other outcomes that are important for patients remains unclear. We conducted a systematic review and meta-analysis to determine the effect of early surgery on the risk of death and common postoperative complications among elderly patients with hip fracture.
methodsWe searched electronic databases (including MEDLINE and EMBASE), the archives of meetings of orthopedic associations and the bibliographies of relevant articles and questioned experts to identify prospective studies, published in any language, that evaluated the effects of early surgery in patients undergoing procedures for hip fracture. Two reviewers independently assessed methodologic quality and extracted relevant data. We pooled data by means of the DerSimonian and Laird random-effects model, which is based on the inverse variance method.
resultsWe identified 1939 citations, of which 16 observational studies met our inclusion criteria. These studies had a total of 13 478 patients for whom mortality data were complete (1764 total deaths). Based on the five studies that reported adjusted risk of death (4208 patients, 721 deaths), irrespective of the cut-off for delay (24, 48 or 72 hours), earlier surgery (i.e., within the cut-off time) was associated with a significant reduction in mortality (relative risk [RR] 0.81, 95% confidence interval [CI] 0.68-0.96, p = 0.01). Unadjusted data indicated that earlier surgery also reduced in-hospital pneumonia (RR 0.59, 95% CI 0.37-0.93, p = 0.02) and pressure sores (RR 0.48, 95% CI 0.34-0.69, p < 0.001).
interpretationEarlier surgery was associated with a lower risk of death and lower rates of postoperative pneumonia and pressure sores among elderly patients with hip fracture. These results suggest that reducing delays may reduce mortality and complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.